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000-081 - System x Technical Principles V9 - BrainDump Information

Vendor Name : IBM
Exam Code : 000-081
Exam Name : System x Technical Principles V9
Questions and Answers : 72 Q & A
Updated On : October 17, 2018
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000-081 exam Dumps Source : System x Technical Principles V9

Test Code : 000-081
Test Name : System x Technical Principles V9
Vendor Name : IBM
Q&A : 72 Real Questions

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IBM IBM System x Technical

lots of of main international organizations installation IBM Cloud inner most | killexams.com Real Questions and Pass4sure dumps

to meet growing to be demand, IBM advances on-prem inner most cloud with new Watson AI capabilities

ARMONK, N.Y., Oct. eleven, 2018 /PRNewswire/ -- IBM (NYSE: IBM) has introduced that in under three hundred and sixty five days considering that the unlock of IBM Cloud inner most – an open supply technology that brings cloud capabilities to agencies working on-premises IT techniques – tons of of leading agencies worldwide have grew to become to the platform to aid modernize their operations. They include New Zealand Police, China's Fuyao neighborhood, Japan's Aflac assurance, Turkey's credit score bureau Kredi Kayıt Bürosu and Brazil's fidelity country wide information capabilities.

IBM supplier brand. (PRNewsFoto/IBM supplier) (PRNewsFoto/) (PRNewsfoto/IBM)

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constructing on this momentum, IBM is saying a slate of latest advanced facets for the on-premises private cloud platform, together with the mixing of effective AI capabilities similar to IBM Watson Assistant and IBM Watson Speech-to-textual content, as well as assist for additional public clouds, together with the IBM Cloud. The updates provide purchasers with even more alternative and flexibility for his or her IT journeys, and, for the primary time, bring the vigor of IBM's Watson AI behind the enterprise firewall.

IBM is releasing particulars of over a dozen corporations which are driving transformation with IBM Cloud inner most, together with:

  • New Zealand Police (NZP) is the use of the newest applied sciences to transform its operations and boost its capacity to tackle crime and maintain the neighborhood protected. NZP is exploring how IBM Cloud deepest and Kubernetes containers can help to modernize its present systems as well as promptly launch new features corresponding to a mobile based communications device for its officers.
  • Fuyao community is China's greatest and most advanced company of automotive glass supplying Audi, Bentley, generic Motors, Toyota and different exact car makers. to satisfy growing demand, Fuyao has embarked on a sensible Manufacturing initiative and is the usage of IBM Cloud private to help combine the management of commercial enterprise purposes across its world manufacturing and business operations, making certain the free flow of assistance across the organization.
  • Aflac assurance, Aflac insurance, a leading company of medical and melanoma coverage featuring insurance policy to 1 in 4 households in Japan, has signed an settlement with IBM to aid simplify and automate its IT infrastructure. With IBM Cloud inner most, Aflac plans to increase the efficiency of its operations and speed up the construction of recent products and features.
  • Kredi Kayıt Bürosu (KKB) offers the country wide cloud infrastructure for Turkey's finance trade. remaining yr KKB based a new records core in Ankara and is now the usage of IBM cloud inner most to assist consolidate and localize the banking systems of over a hundred and fifty contributors including banks and other monetary features corporations. With IBM Cloud deepest, KKB is able to pressure innovation across its fiscal capabilities ecosystem while meeting the high requirements for facts security and privateness.
  • Brazil's constancy national counsel functions (FIS), a global leader in fee processing options for the monetary industry, has adopted IBM Cloud inner most to help streamline bank card chargebacks for its Brazilian operations. IBM Cloud inner most is assisting FIS to orchestrate the quite a lot of IT techniques worried in reconciling and checking of transaction chargebacks whereas assembly the stringent regulatory necessities of the trade and assisting to avoid fraud.
  • "The cloud has evolved in a really brief time from being a method to reduce charges to a platform for company transformation and innovation," stated Robin Hernandez, Director, IBM private Cloud providing management. "Our IBM Cloud deepest affords consumers a transition to cloud this is designed to enable them to preserve their on-premises systems on which they still rely for a lot of mission-essential functions and sensitive information units."

    placing AI internal the EnterpriseToday IBM is advancing IBM Cloud private even extra, saying predominant enhancements to the platform, starting from AI capabilities to further public cloud aid. starting these days, IBM Watson Speech-to-textual content is now accessible with the brand new IBM Cloud private version three.1, making it the first time the device is attainable in an on-premises ambiance. With Watson Speech-to-textual content, users can instantly transcribe and analyze audio from seven diverse languages.

    furthermore, IBM Watson Assistant is now attainable on IBM Cloud private. The Watson Assistant platform helps developers and non-technical clients to create conversational AI solutions, from standard chatbots to advanced business grade solutions for consumer carrier and extra.

    IBM additionally announced nowadays that IBM Cloud private is now purchasable on the IBM Public Cloud, to help clients to with no trouble circulation their business workloads from on-premises systems to the public cloud with the intention to create hybrid cloud environments.

    client quote"IBM Cloud private is assisting us to establish an end-to-end digital platform so one can underpin a smarter, greater agile, and extra flexible company working structure," spoke of Mr. Lebing Xia, vice chairman and CIO of the Fuyao group. "And by using enabling us to connect to different cloud-primarily based capabilities like AI, Blockchain and IoT, we can be capable of get much more enterprise cost from the cloud."

    Analyst quoteAccording to IDC's worldwide Quarterly 2Q18 Cloud IT Infrastructure Tracker, September 2018, complete worldwide spending on cloud IT infrastructure is expected to complete $62.2 billion in 2018 with yr-over-year boom of 31.1%. whereas public cloud datacenters will account for almost all of this spending, on-premises deepest clouds will account for essentially 20% of the whole cloud IT infrastructure market, transforming into at 19.3% yr over yr in 2018. "businesses have quite a number enterprise and IT needs some of that are well served with the aid of public cloud choices and a few which aren't," observed Natalya Yezhkova, research Director, IDC. "On-premises deepest cloud is an impressive option for dependent companies that are seeking for a gradual method for remodeling their firm whereas preserving manage of their IT infrastructure."

    Story Continues

    About IBM CloudWith $18.5B in annual cloud earnings, IBM is the international chief in business cloud with a platform designed to fulfill the evolving wants of business and society. moving previous productiveness and value improvements, the IBM Cloud is tuned for the AI and data calls for which are driving true differentiation in today's enterprise. IBM's private, public and hybrid choices deliver the world scale companies need to help innovation across industries.

    built on open source frameworks Docker containers and Cloud Foundry, and managed with the Kubernetes container architecture, IBM Cloud deepest allows organizations to advance cloud-native functions and additionally modernize on-premises applications in order to deploy them in either private cloud settings or the general public cloud of their alternative.

    Media contacts:Jonathan BattyIBM Media family members (Europe)jjbatty@ibm.com

    Michael ZimmermanIBM Media members of the family (US)mrzimmerman@us.ibm.com

    Notes for journalists and editorsExamples of different leading international corporations remodeling with IBM Cloud inner most:

    CNH Industrial, ItalyCNH Industrial, a pacesetter in the capital items sector working within the agricultural and development equipment, commercial cars, strong point automobiles and powertrain segments, has signed a multi-yr cloud settlement with IBM. in the course of the deal it'll use IBM Cloud private and Watson artificial Intelligence to radically change its business processes - from manufacturing to give chain, earnings & advertising and marketing and monetary services. IBM Cloud deepest will aid CNH Industrial to optimize its management of enterprise applications while nevertheless benefitting from the safety of manage of its personal on-premises infrastructure. The agility and flexibility of ICP has the long-time period capabilities of generating better efficiencies in application construction and could allow faster time to market for new imaginative client capabilities.

    Klirinski Interbankarski Sistemi advert Skopje (KIBS), Macedonia Klirinski Interbankarski Sistemi advert Skopje (KIBS), a Macedonia-based payment gadget operator owned by way of 12 banks is working with IBM to transform price clearing techniques and guide sooner the integration of Macedonia's banking system with the eu. With IBM Cloud private KIBS can be capable of consolidate and seriously change their present substances right into a "digital factory" able to developing and working contemporary cloud-native functions on the fly. it's hoped that this transformation will in the reduction of time to market for new digital items from one-and-a-half years to just a couple of months, whereas optimising working expenses and helping KIBS' compliance activities regarding stringent banking regulations.

    Sentient.io, SingaporeSentient.io, one of Singapore's leading artificial Intelligence corporations, is working with IBM to bring on its mission to enhance regular life by using making human and computing device interactions more herbal and pervasive.Sentient.io has chosen the IBM Cloud inner most as a platform to host Singapore's first AI-as-a-carrier (AaaS) platform to permit its valued clientele to radically change and automate their agencies with AI capabilities akin to belief, knowing, self-learning and difficulty-fixing. the usage of IBM Cloud private, Sentient.io will assist govt and commercial enterprise valued clientele to meet strict information protection and privacy necessities, modernize current functions by moving them to the cloud, and quite simply manage the lifecycle of their digital assets.

    Ilmarinen, FinlandIlmarinen, the greatest private insurer in Finland responsible for the pensions of over 1.1 million finish citizens and more than EUR forty five billion in funding belongings, has shifted functions to IBM Cloud inner most to enable it to develop new digital services whereas maximizing its existing IT infrastructure. through inserting its application construction pipeline onto IBM Cloud inner most, Ilmarinen is able to tremendously pace up development cycles and reduce infrastructure costs, cutting the total software release time from days to minutes. here's above all important with improved force on the realm's pension techniques as a result of an growing older inhabitants.

    Techniker Krankenkasse (TK), GermanyGermany's largest statutory health insurance fund Techniker Krankenkasse (TK) is the use of IBM Cloud inner most for a brand new carrier referred to as TK-secure which offers valued clientele with their medical health insurance information by means of their smartphone - regardless of time and location. IBM is already presenting suggestions as-a-provider to TK-protected's relaxed records vault which includes the encrypted health statistics of TK's coverage customers across Germany. by the use of an open carrier platform, TK-secure is capable of immediately and easily boost and launch new value-brought features for insured persons, insurance companies, provider providers and hospitals.

    Mangalore university, IndiaMangalore institution, one among India's exact public education associations, will provide new-age lessons in rising technologies through its affiliated schools and is leveraging the power of IBM Cloud private to give a common platform that will also be accessed remotely through any student. IBM Cloud inner most will run on the school's IBM power servers as part of a comprehensive answer which additionally includes QRadar, MaaS360 and Cognos application. The answer will be integrated through Nihon conversation options, an training delivery companion of IBM, which is answerable for the beginning of advanced lessons on cybersecurity and big information Analytics and provides excessive-performance structures for network and protection purposes.

    SK Holdings C&C, Ltd., South KoreaSK Holdings C&C, a leading IT features enterprise and IBM business associate in South Korea became to IBM Cloud inner most to right now and simply package applications as containers and re-ingredient them with IBM microservices. additionally, the enterprise is leveraging the utility to assist customers modernize their legacy purposes and supply a at ease platform from which to run enterprise critical application throughout each public and private clouds, in a true multi-cloud architecture.

    Five9 Vietnam Corp., VietnamFive9 Vietnam is a fast-transforming into IT and cloud carrier issuer that provides its purchasers with every little thing from cell and analytics utility development, to inner most and public cloud capabilities. The company has been the use of IBM Cloud private given that April to design, boost, and kit functions as containers for handy deployment on the public cloud. From there, their customers can faucet into IBM microservices, comparable to analytics, AI and blockchain, to extend their functionality even additional.

    View normal content to download multimedia:http://www.prnewswire.com/news-releases/tons of-of-main-world-agencies-installation-ibm-cloud-inner most-300729130.html


    The Winds Are altering In Servers -- AI ends up in opportunity for IBM & energy | killexams.com Real Questions and Pass4sure dumps

    IBM and the vigour architecture excel at AIIBM

    There has not ever been a single processor architecture for server functions as a result of no two workloads are the equal. however, for the previous decade, Intel has all however dominated the server market, shutting out AMD, the most effective other x86 server seller, and leaving only HPC, mainframe, database and other really expert applications for different processor architectures. With the trade facing challenges due to a becoming checklist of safety vulnerabilities from defective speculative execution implementations, altering workload necessities, slowing of Moore’s law, and imaginative new processor architectures, server OEMs and valued clientele are all taking a look at making adjustments. many of the new processor providers are specializing in specific segments to goal. IBM seems the ideal located to advantage from the enormous activity in AI.

    moreover the altering technical and market dynamics, Intel has also stumbled in each manufacturing manner and structure. they've struggled to transition to the 14nm and 10nm system nodes and now appear neatly behind Samsung and TSMC, the major leading foundry carrier providers, in transitioning to the 7nm technique node. in addition, Intel has purposely confined memory bandwidth in its Xeon processors to promote two-socket servers over single-socket configurations. This has created a renewed chance for the IBM with its energy structure.

    by leveraging these leading foundries, IBM has the flexibility to leverage the optimum density and most comparatively cheap process expertise. moreover, IBM has concentrated the design of the vigor structure on standard equipment performance and leveraging application, corresponding to PowerAI, for stronger data flows. The enviornment it really is vital in each AI practicing and inference is bandwidth to reminiscence, to accelerators and to the network. IBM’s vigor architecture now not handiest supports greater reminiscence than competitive Xeon platforms, however it additionally delivers approximately 10x the bandwidth to accelerators with NVLink. NVIDIA is the leader in AI accelerators with its Tesla line of GPU accelerators and vigor is the only processor architecture the use of NVIDIA’s NVLink interface without delay within the processor itself which enormously improves performance. additionally, the NVLink is coherent, which permits the GPUs to have direct access to the gadget reminiscence enabling enormous AI models up to 2TB in dimension in preference to being restrained to simply the GPU reminiscence.

    while Intel Xeon’s are used as the host processor in most of the installed statistics core neural networks, clients will see a benefit to leveraging accelerated structures with greater performance and bandwidth.

    The IBM AC922 vigor-based mostly platform that leverages Nvidia GPUs and NVLink for greater gadget bandwidthIBM

    although, the hardware is only half the story. apart from the hardware advancements, IBM also developed tools expanding the ability of open source frameworks like TensorFlow and Caffe, as well as offering a machine-gaining knowledge of library known as Snap ML that further reduces the working towards of new neural networks by means of leveraging generalized linear models in preference to starting from scratch. lots of the libraries are being developed primarily for emerging functions like photograph and video focus. In the use of the ImageNet dataset, IBM claims that may train neural networks as much as 4 times quicker than a Xeon-based equipment. With Caffe, IBM was capable of take the training of a neural network from hours down to minutes while making it simpler for statistics scientists to make use of more intuitive tools in preference to getting to know to code.

    The IBM hardware and application vigor platform for AIIBM

    IBM's distributed Deep getting to know (DDL) utility for expanded scaling efficiencyIBM

    IBM additionally developed distributed Deep getting to know (DDL) utility that, along side the vigour structure, makes it possible for for better scaling of efficiency for giant equipment configurations using assorted servers each with distinctive GPUs, virtually improving the parallelization that will also be carried out with tremendous workloads.  With DDL, IBM architected 95% effectivity with 256 NVIDIA GPUs in 64 IBM vigour methods.

    a further entertaining element of IBM is that it presents quite a number systems for on-premises records centers to the significant cloud facts centers, and even presents AI as a provider with access to its personal facts core supplies leveraging vigour.

    As workloads exchange, server shoppers are searching for more options to meet an increasing array of performance requirements by way of the turning out to be variety of distinctive workloads. in the case of AI, IBM has developed a spot in mixture with its companion NVIDIA that provides a platform that offers the optimum efficiency in AI. in addition, IBM offers a full range of finished platforms and functions that take lots of the technical challenges out of facts science. TIRIAS analysis is evaluating every of the server processor architectures to see how and where they slot in the changing server atmosphere. With different analysis in AI, such as Watson, IBM seems to have discovered a powerful position for the vigour platform.

    The writer and individuals of the TIRIAS research personnel do not grasp fairness positions in any of the companies outlined. TIRIAS research tracks and consults for businesses all through the electronics ecosystem from semiconductors to systems and sensors to the cloud. participants of the TIRIAS analysis group have consulted for IBM, Intel, and NVIDIA.


    IBM challenges Pentagon’s $10 billion cloud computing effort days before bids are due | killexams.com Real Questions and Pass4sure dumps

    Aaron Gregg

    Reporter overlaying protection contractors and Washington-enviornment businesses

    October 10

    IBM is challenging the defense department’s determination to show to a single company for its $10 billion departmentwide cloud computing infrastructure, a company government said Wednesday. The latest legal difficulty to complicate the Pentagon’s plans has come days before bids are due.

    An government widespread with the company’s method proven Wednesday that IBM has filed a pre-award bid protest with the govt Accountability workplace, which guidelines on bid protests.

    The contract, time-honored because the Joint enterprise defense Infrastructure (JEDI), requires the creation of a massive cloud-computing gadget that can allow new weapons capabilities and keep classified facts. The JEDI cloud is expected to take in one of the most Pentagon’s present efforts and is considered a “pathfinder” that the defense department will construct upon for many years. Whichever enterprise is awarded the contract will not only get hold of billions of greenbacks in federal funding however additionally can have a robust foothold from which to compete for other alternatives.

    Bids are due Friday, and Amazon net functions, Microsoft, IBM and Oracle are anticipated to compete for the opportunity. Amazon is largely regarded a entrance-runner for the contract because it has been the CIA’s basic cloud service issuer for years. Google announced this week that it could no longer bid on the contract. (Amazon.com founder and chief executive Jeffrey P. Bezos owns The Washington put up.)

    defense branch officers noted in early March that the $10 billion, 10-12 months contract would be bid out to a single cloud provider.

    The defense department has made the case that the usage of more than one issuer would add pointless complexity.

    “We’ve on no account developed an business cloud,” observed Dana Deasy, the Pentagon chief assistance officer overseeing the process. “starting with a few companies while on the identical time making an attempt to construct out an business capability simply comfortably did not make sense.”

    Amazon executives have praised that method in media interviews, saying the defense department doesn't yet have the technical awareness and team of workers capabilities to control a large number of providers.

    IBM, Microsoft and Oracle have sharply criticized the govt’s single-provider tack for the past six months, asserting that turning to at least one would lock the government out of improvements going on at other businesses and increase fees by way of shutting out would-be opponents.

    IBM’s bid protest has not been made purchasable by the enterprise. however Sam Gordy, head of the business’s federal business, described elements of IBM’s strategy for the protest in an interview Tuesday with The post.

    The bid protest flies in the face of the govt’s decision to show to a single company for the contract, echoing a prison challenge that application tremendous Oracle filed in early August. however IBM took that criticism a step further in arguing that the single-award strategy would battle with the White house’s “Cloud sensible” method, which emphasizes leveraging the ultimate options from government and commercial business.

    “Given what DOD is making an attempt to do with this cloud — a single award, and lock-in for 10 years — [picking just one provider] is absolutely contrary to their objectives,” he talked about. “This DOD cloud award is fully contrary to what the [Trump] administration has been announcing as far as cloud smart.”

    Gordy additionally reiterated issues that the procurement may be biased in prefer of Amazon. The company’s competitors are involved that Amazon has an interior music to the JEDI award on account of its prior work with the CIA, and since the request for proposals contains definite federal information expertise certifications that handiest Amazon is likely to meet and which played a valuable position in Google’s determination to drop out of the competitors. IBM executives say the enterprise may have “some, but not all” of the necessary certifications as of the Friday due date.

    “There are features of the [JEDI request for proposals] that obviously indicate a undeniable dealer in mind,” Gordy spoke of Tuesday.

    The company one by one described features of its felony strategy in a draft blog put up it is to be published on the company’s site. in the publish, IBM observed the Pentagon’s single-supplier method for the JEDI contract would additional undermine the branch’s cybersecurity posture.

    “JEDI’s single-cloud approach also would give unhealthy actors just one goal to focus on may still they wish to undermine the military’s IT spine,” the business wrote in a draft shared with The submit. “the realm’s largest organizations are increasingly moving in a multi-cloud direction on account of security, flexibility and resilience; the Pentagon is relocating in precisely the opposite path.”

    IBM executives appear to don't have any qualms about the opportunity that a deluge of criminal movements may impede the contract thoroughly, asserting it would be more advantageous to restart the technique and turn to multiple providers.

    “Getting it off the ground if you’re doing it the wrong manner doesn’t serve the nation,” Gordy stated. “better to do it the appropriate way.”




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    Principled Technologies Replies to Controversy Surrounding Their Intel i9 9900K vs AMD Ryzen 7 2700X Benchmark | killexams.com real questions and Pass4sure dumps

    Following the official release date, pricing and specs announcement of the Intel i9 9900K CPU, Intel shared several game benchmarks where the processor crushed all competition, including the AMD Ryzen 7 2700X. Some of these benchmarks were published by PCGamesN, but renown YouTube channel Hardware Unboxed quickly pointed out in a video titled Intel’s New Low: Commissioning Misleading Core i9-9900K Benchmarks that the AMD Ryzen 7 2700X CPU had been handicapped by suboptimal memory timings used in the test.

    Following these reports, we reached out to Principled Technologies (which conducted the benchmark commissioned by Intel) asking for a comment. We just got a reply from Bill Catchings, co-founder of Principled Technologies, and we’ve posted it below as is.

    Today, we have seen several reports that suggested Principled Technologies (PT) published misleading information in our recent study comparing Intel’s gaming processors to AMD’s. We apologize for our delay in responding, but it’s been a busy day, and we wanted to be as thorough as possible in addressing inquiries concerning our testing. We’ll address specific questions and share more detail on our methodology in a moment, but we first must respond directly to attempts to call our integrity into question.

    For almost 16 years, we have tested products for our clients because they trust our integrity. We have worked not just for any one company but for dozens of the leading technology firms, including rivals such as Intel and AMD, Microsoft and Google, Dell and HP, and many others.

    Those clients trust PT in part because our integrity and our technical knowledge are beyond reproach. We work hard to be the best in both of those areas. We chose our company name to emphasize our commitments to both technology and our principles. (And, accusers saying we are only in this for the money obviously haven’t read our book, Limit Your Greed!)

    Before going further, we thus must categorically deny any dishonesty in our work on this project for Intel or in any of our other projects.

    Now that we’ve gotten that off our chests, let’s address the specific questions from recent videos as well as subsequent posts and tweets.

    An overview of the project will provide useful context.

    Our overall goal – and Intel’s specific request for this project – was to create as level a playing field as possible for comparing the AMD and Intel processors as the majority of the gaming market would likely use them. To do that, we built and configured 16 systems for this comparative testing; we had two of each processor/motherboard configuration. We matched all components where possible, the only variances being the motherboards, CPUs, and CPU coolers. (Full details are in our interimreport.)

    In an effort to be very transparent, we published our interim summary report on Oct 8, 2018. We will continue to be transparent and responsive to any questions.

    We have received a number of inquiries regarding the testing methodology we used and the potential for bias in favor of Intel. We are providing additional information to be as transparent as possible and to help allay these concerns.

    The following list summarizes many of the inquiries we have received and our responses. (We are continuing to work on addressing additional inquiries.)

  • Use of “Game Mode” on the AMD Ryzen™ 7 2700X: Some inquiries we have received concern the use of the Ryzen utility and the number of active cores in the AMD-based systems. Based on AMD’s recommendations and our initial testing on the Threadripper processors, we found installing the AMD Ryzen Master utility and enabling the Game Mode increased most results. For consistency purposes, we did that for all AMD systems across Threadripper™ and Ryzen™. We are now doing additional testing with the AMD systems in Creator Mode. We will update the report with the new results.

  • Cooler choice: We chose Noctua for the CPU coolers, due to having almost identical systems in the NH-U14S (Intel) and NH-U14S TR4-SP3 (AMD), which allowed us to maintain a comparable thermal profile. Because we were not performing any overclocking on any configuration, and because AMD has said it was a good cooler, we stuck with the stock AMD Ryzen™ 7 2700X Wraith Prism cooler.

  • Memory speeds: To have complete parity across all systems, and to allow the Intel® Core™ i9 X-series and AMD Ryzen™ Threadripper™ to fully utilize memory bandwidth, we used 4 16GB DDR4 DIMMs on all configurations. We took the following memory configuration steps:

  • Intel:

    o Asus Prime Z370-A (i7-8086K,i7-8700K)

  • Load Optimized BIOSdefaults

  • Enabled: Extreme Memory Profile(X.M.P.)

  • Disabled ASUS MultiCore Enhancement to use stock intel multicore settings

  • DRAM Frequency set toDDR4-2666

  • Power saving & Performance mode, set toPerformance

  • AMD:

  • Resolution settings: One goal of this study was to test the CPUs and their graphics subsystems, not the GPUs, so we ran the tests at the most common gaming resolution (62.06%), 1920×1080, according to the Steam Hardware Survey: https://store.steampowered.com/hwsurvey/Steam-Hardware-Software- Survey-Welcome-to-Steam. This allowed us to minimize any GPU-based bottlenecks on the rendering pipeline.

  • Quality settings: We configured all games to use the “High” or equivalent preset, versus “Ultra” or other presets, also to emphasize CPU over GPU performance. In the case where there were only three presets, we chose the top preset.

  • Clarification of various installation questions: We installed all games using Steam or the Microsoft Store, and fully updated with the latest patches.

  • Motherboards: Re a Twitter comment from Cyber Cat @0xCats, “Hey @AMD Apparently according to @PrincipledTech @Intel is able to run Ryzen™ & Threadripper™ Chips on Z370 and Z390”: Thanks for catching that copy/paste error in our configuration info. We made an error there. The correct processor/motherboard/BIOS version specs for the AMD procs we tested are the following: Ryzen™ 7 2700X/ASUS PRIME X470-PRO/4024 and Threadripper™ 2950X & 2990WX/ASUS PRIME X399-A/0807. We apologize for the error and will post a revised version (with changes noted) soon.

  • Because our goal is always to do the right thing and get the answers right, we are currently doing additional testing. We will share that data and will certainly call out if something is significantly different from what we’ve already published.

    We are confident in our test methodology and results. We welcome questions and we are doing our best to respond to questions from our interim report, but doing so takes time. We will add responses if other issues come up.

    Thanks for listening.

    Here’s our Keith discussing the original report made by Hardware Unboxed.

    Share Submit


    Fact-checking President Trump’s USA Today op-ed on ‘Medicare-for-All’ | killexams.com real questions and Pass4sure dumps

    President Trump wrote an opinion article for USA Today on Oct. 10 regarding proposals to expand Medicare to all Americans — known as Medicare-for-All — in which almost every sentence contained a misleading statement or a falsehood.

    Many of these are claims we have already debunked. Presumably, the president is aware of our fact checks — he even links to two — but chose to ignore the facts in service of a campaign-style op-ed. Medicare-for-All is a complex subject, and serious questions could be raised about the cost and how a transition from today’s health-care system would be financed. Trump correctly notes that studies have estimated that the program — under the version promoted by Sen. Bernie Sanders (I-Vt.) — would add $32.6 trillion in costs to the federal government over 10 years. (He doesn’t mention that costs in theory would go down for individuals, state governments and others, so overall national health expenditures may not increase and could even decrease.)

    But this is not a serious effort to debate the issue. So as a reader service, we offer a guide through Trump’s rhetoric.

    “Throughout the year, we have seen Democrats across the country uniting around a new legislative proposal that would end Medicare as we know it and take away benefits that seniors have paid for their entire lives.”

    Sanders has unveiled a plan he calls “Medicare-for-all.” Essentially, it is a single-payer plan. That means all of the bills would be paid by one entity — the federal government — in contrast to the hodgepodge health-care system now in place. Medicare, the health care system for the elderly and disabled, is a federal single-payer plan, but people under 65 get insurance from employers, through the individual market (Obamacare) or through Medicaid, the federal-state health system for the poor. Private health insurance plans, such as those offered through employers, would be eliminated, according to the Congressional Research Service.

    Sanders says he would first improve Medicare for seniors and the disabled by eliminating deductibles and covering dental, vision and hearing aids, which are not covered under current law. Then, over the course of four years, the eligibility age would be lowered in stages until every American was covered.

    On paper at least, the Sanders plan would improve benefits for seniors, not take them away.

    There are several other versions, including proposals more limited in scope (such as “Medicare-X”) that would simply offer a Medicare option as a buy-in. The Kaiser Family Foundation has a useful guide to the differences.

    “As a candidate, I promised that we would protect coverage for patients with pre-existing conditions and create new health care insurance options that would lower premiums. I have kept that promise, and we are now seeing health insurance premiums coming down.”

    Trump made this promise, but broke it. He supported Republican plans that would have weakened protections for individuals with preexisting conditions. His administration also has refused to defend the Affordable Care Act against a lawsuit that would undermine those protections. In effect, the Trump administration no longer supports a provision of the ACA, a.k.a. Obamacare, that makes it possible for people to buy insurance if they have preexisting health conditions. (We labeled this as a flip-flop.)

    As for premiums, they have continued to increase on average, just at a lower rate than in the past. But experts say that without Trump’s moves to weaken the Affordable Care Act, premiums would be even lower in many states.

    “I also made a solemn promise to our great seniors to protect Medicare. That is why I am fighting so hard against the Democrats' plan that would eviscerate Medicare.”

    Under Trump, the date for when the Medicare Hospital Insurance (Part A) trust fund will be depleted keeps advancing. The current projection is 2026, three years earlier than the projection a year earlier.

    Part A is financed mainly through payroll taxes of 1.45 percent on earnings paid both by workers and employers; self-employed people pay 2.9 percent. The money raised is then credited to a pay-as-you-go trust fund, which uses the revenue raised to pay the benefits of Medicare beneficiaries.

    With the baby-boom generation retiring at a rate of 10,000 people per day, that puts pressure on the long-term financing of the program because fewer workers will be supporting more retirees. If the trust fund is depleted, that means the government would not be able to cover 100 percent of estimated expenses. Yet because of Trump’s tax cut, the budget deficit is soaring even as the economy is booming, in contrast to previous periods of under-4-percent unemployment. That leaves the government less prepared to deal with the consequences of baby-boom retirements.

    “Democrats have already harmed seniors by slashing Medicare by more than $800 billion over 10 years to pay for Obamacare.”

    Trump resurrects a misleading Republican talking point from the 2012 election.

    The Affordable Care Act actually strengthened the near-term outlook of the Part A trust fund. The law includes a 0.9 percent payroll tax that hits the wages and self-employment income of wealthier Americans — above $250,000 per couple or $200,000 for a single taxpayer. That was estimated to raise an additional $63 billion for the Part A trust fund between 2010 and 2019. The law also was estimated to cut expenses, including $162 billion in productivity adjustments to provider payments and $86 billion in reduced payments to Medicare Advantage plans. The net result was that the “insolvency” date was extended by 12 years.

    In other words, the savings that Trump complains about mostly were wrung from health-care providers, not Medicare beneficiaries — who, as a result of the health care law, ended up with new benefits for preventive care and prescription drugs.

    Moreover, the $800 billion in Medicare reductions in the ACA that Trump complains about are the law of the land. In fact, Republicans in Congress and the Trump administration in their budget plans have pocketed virtually all those savings — and sought even more reductions in Medicare spending on top of that. Trump proposed $350 billion in net Medicare cuts in his budget — and there were about $540 billion in Medicare cuts assumed in the House GOP budget plan.

    “The Democrats' plan means that after a life of hard work and sacrifice, seniors would no longer be able to depend on the benefits they were promised.”

    As noted, the Sanders plan in theory would expand benefits for seniors.

    “The Democratic plan would inevitably lead to the massive rationing of health care. Doctors and hospitals would be put out of business. Seniors would lose access to their favorite doctors. There would be long wait lines for appointments and procedures. Previously covered care would effectively be denied.”

    This is a scare scenario. Obviously, a transition to single-payer health care would lead to upheaval and uncertainty since it would encompass the entire health care system, not just the small piece covered by Obamacare. But other countries appear to manage with single-payer systems, at lower costs than the United States. Trump’s vision of what would happen under single-payer echoes the fears evoked by opponents of Medicare in the 1960s and Obamacare in 2010. So there’s a Chicken-Little feel to this language.

    Here, for instance, is Ronald Reagan in 1961, warning against the creation of Medicare.

    “The Democrats' plan also would mean the end of choice for seniors over their own health-care decisions. Instead, Democrats would give total power and control over seniors’ health care decisions to the bureaucrats in Washington, D.C.”

    Medicare is currently a government-run program, with hospital and doctor fees paid by the government, so this appears to be an absurd point.

    “The new Democrats are radical socialists who want to model America’s economy after Venezuela.”

    Venezuela is collapsing after years of near-dictatorship and squandering of oil wealth, but we are unaware of any Democratic leader who has pointed to Venezuela as an economic model.

    “Some Democrats' absolute commitment to end enforcement of our immigration laws by abolishing Immigration and Customs Enforcement. That means millions more would cross our borders illegally and take advantage of health care paid for by American taxpayers.”

    Some Democrats have been calling to abolish U.S. Immigration and Customs Enforcement, but it’s not a widely held position. Other Democrats say the agency should be reformed, not abolished. In any case, ICE is only one of several agencies tasked with immigration enforcement.

    “Democrats will seek to slash budgets for seniors’ Medicare, Social Security and defense.”

    Trump may have a point about defense spending, never a favorite among the left, but the president’s $1 trillion deficits will put pressure on all aspects of government, no matter who is in power. Democrats generally have pushed to expand Social Security benefits, not cut them.

    “Republicans believe that a Medicare program that was created for seniors and paid for by seniors their entire lives should always be protected and preserved.”

    As a technical matter, current retirees receive far more in benefits than they have paid into the system, according to the Urban Institute; younger workers are going to have subsidize the baby-boomers moving into retirement.

    Meanwhile, for years, House Republicans led by Speaker Paul D. Ryan (R-Wis.) have pushed for a significant overhaul of Medicare. Retirees would get from the government what Ryan called “premium support” — a set payment adjusted to inflation; they would have used that money to pick from a range of plans offered by insurance companies through what is termed a Medicare exchange. But the Congressional Budget Office raised significant questions about whether the premium payment would be adequate over time.

    The CBO analysis estimated that by 2030, the government would pay just 32 percent of the health care costs, less than half of what the federal plan currently pays. The other 68 percent of the plan would have to be shouldered by the retiree.

    Ironically, Democrats successfully attacked the plan as ending “Medicare as we know it.”

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    Share the Facts

    2018-10-10 16:40:02 UTC

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    “Democrats have already harmed seniors by slashing Medicare by more than $800 billion over 10 years to pay for Obamacare.”

    Donald Trump

    President

    https://www.usatoday.com/story/opinion/2018/10/10/donald-trump-democrats-open-borders-medicare-all-single-payer-column/1560533002/

    in an op-ed for USA Today

    Wednesday, October 10, 2018

    2018-10-10

    Share the Facts

    2018-10-10 16:37:59 UTC

    -1

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    False

    “As a candidate, I promised that we would protect coverage for patients with pre-existing conditions and create new health care insurance options that would lower premiums. I have kept that promise, and we are now seeing health insurance premiums coming down.”

    Donald Trump

    President

    https://www.usatoday.com/story/opinion/2018/10/10/donald-trump-democrats-open-borders-medicare-all-single-payer-column/1560533002/

    in an op-ed for USA Today

    Wednesday, October 10, 2018

    2018-10-10


    How to discover a new drug (and why it’s so difficult) | killexams.com real questions and Pass4sure dumps

    Excerpted with permission from The Drug Hunters: The Improbable Quest to Discover New Medicines by Donald R. Kirsch and Ogi Ogas. Copyright 2018 by Arcade Publishing, an imprint of Skyhorse Publishing, Inc.

    After spending my entire career searching for new medicines, I’ve learned that the only sure thing in the drug hunting business is that you almost never end up with the exact drug you started stalking. The vast majority of my colleagues, all educated at top-flight research universities and working at posh laboratories festooned with high-tech gear, have spent their entire careers groping through the labyrinth of bio-active molecules without ever finding a new compound that safely and effectively improves human health.

    The professor who trained me in pharmacology, an MD, once told me that 95 percent of the time a patient visits a physician he will not actually be helped by the doctor. In most cases, either the patient’s body will heal itself without needing the doctor’s intervention or the disease will be untreatable, rendering the physician powerless. In his view, the physician has the ability to make a meaningful difference to his patients only 5 percent of the time. While that may seem low, those are fantastic odds compared to the ones faced by the drug hunter.

    Only about 5 percent of a scientist’s ideas for a drug discovery project get funded by management. Of these, only 2 percent end up producing an FDA-approved medicine. That means a drug hunting scientist can only expect to make a difference about one tenth of 1 percent of the time. Finding new drugs is so challenging, in fact, that it has led to a crisis in the pharmaceutical industry. Big Pharma companies are becoming increasingly frustrated with the massive research expenditures necessary to come up with new drugs—an average of about $1.5 billion and fourteen years for each FDA-approved drug—and the exasperating fact that the vast majority of their endeavors don’t produce a usable drug. Executives at Pfizer recently told me they are thinking about getting out of the drug-discovery industry entirely. Instead, they want to be in the drug acquisition industry: they would prefer just to buy drugs that other people have invented. Think about that. Finding new drugs is so formidable that one of the oldest, most talented, and wealthiest drug makers—the largest drug maker in the world, in fact—would rather let other people deal with the problem.

    So why is the “degree of difficulty” of finding new drugs so much greater than, say, landing a man on the moon or designing an atomic bomb? The moon shot and the Manhattan Project employed well-established scientific equations, engineering principles, and mathematical formulas. They were formidable and grueling endeavors, to be sure, but at least the researchers possessed clear scientific road maps and mathematical compasses to guide them. The moon shot engineers knew with certainty the distance from the Earth to the moon, and how much fuel was needed to get there. The Manhattan Project scientists knew that matter could be turned into city-obliterating energy according to E=mc2.

    In contrast, the core challenge of designing a new drug — the trial-and-error screening of immense numbers of candidate compounds — is a task not guided by any known equations or formulas. While an engineer knows if his bridge will bear weight before he ever lays a girder down, a drug hunter has no clear idea how a particular drug will work until a human subject actually ingests it.

    In the mid-nineties, chemists at Ciba-Geigy (now a part of Novartis) calculated the total number of possible drug compounds in our universe: 3 x 1062. When it comes to characterizing the size of a number, some numbers are big, some are enormous, and some are so incomprehensibly, inconceivably large that they might as well be infinity. The number 3 x 1062 falls into that third category. If you were able to test one thousand compounds every second to see if any of them could serve as an effective remedy for a particular malady—say, breast cancer—by the time our sun burned out you would still have not made a measurable dent in the total number of breast cancer-fighting drug possibilities.

    There is a story by the blind Argentinean author Jorge Luis Borges that I think perfectly captures the central challenge of drug hunting. In “The Library of Babel,” Borges imagines that the universe is a library consisting of an infinite number of hexagonal rooms that extend forever in every direction. Each room is filled with books. Each book contains a random arrangement of letters, and no two books are the same. Once in a while, purely by chance, a book contains an entire readable sentence, such as “The gold is in the mountain.” But, as Borges puts it, “For every rational line or forthright statement there are leagues of senseless cacophony, verbal nonsense, and incoherency.”

    Nevertheless, the library must contain books that, purely by chance, are filled with legible life-changing wisdom. Such books are known as “Vindications.” In Borges’s fantasy, solitary searchers known as librarians wander endlessly through the library, hoping to find these Vindications. Most librarians wander through the endless hexagons in vain, spending their life coming across nothing but nonsense. But Borges notes that there are librarians who, through good fortune or sustained force of will, have managed to discover a Vindication.

    Similarly, every possible drug is contained somewhere in the vast theoretical library of chemical compounds. There is a molecular configuration that will safely destroy ovarian cancer, another that will halt the corrosive advance of Alzheimer’s, another that will cure AIDS—or maybe they do not exist at all. There is no way to know for sure. Modern drug hunters are like Borges’s Babelian librarians, forever questing for life-changing compounds and always suppressing their secret fear that the vindicating medicines may never be found.

    The problem, ultimately, is the human body. Our physiological activity is not a closed, well-defined system like rocket propulsion or nuclear fission. It is an open and unfathomably arcane molecular system with innumerable undefined relationships among its components, rendered even more abstruse by the fact that each person’s body has their own idiosyncratic structure and dynamics. We only understand a tiny fraction of these physiological relationships and have not yet deciphered how most of our body’s basic molecular components actually work. Complicating matters still further is the fact that each individual has her own idiosyncratic genetic and physiological architecture, so that each person’s body operates slightly (or extremely) differently. Even more daunting, despite tremendous advances in our understanding of cells and tissues and organs, we simply cannot precisely predict in advance how a given chemical compound will interact with a given molecule in a living body. In fact, it is impossible to know with certainty if a particular disease possesses what pharmacologists call a “druggable protein” or a “druggable target”—some specific protein associated with a pathology that can be influenced by a chemical agent.

    Designing an effective drug requires two things: the right compound (the drug) and the right target (the druggable protein). The drug is like a key that turns the protein lock to start the ignition on a physiological engine. If a scientist wants to intentionally influence a person’s health in a specific way—to reduce depression, relieve itching, treat food poisoning, or produce any other health benefit—she must first identify a target protein that influences the relevant physiological processes in the human body or that, conversely, interferes with the physiological processes of a pathogen.

    For example, Lipitor acts upon HMG-CoA reductase, the protein controlling the rate of the body’s synthesis of cholesterol. Penicillin, in contrast, shuts down peptidoglycan transpeptidase, a protein required to synthesize the (essential) cell wall of a bacterium. But finding the drug key that will turn a protein lock . . . As Hamlet would say: Ay, There’s the rub! This is the daunting challenge for the drug hunter. Despite the humbling odds, some drug hunters, such as Suren Sehgal, through unwavering resolution or outrageous fortune, through individual genius or far-flung collaborations, have stumbled upon their Vindications.

    The term drug hunters have bestowed upon the process of systematically searching through a library of compounds is screening. The prehistoric screening method consisted of snatching every new berry or leaf you came across and snorting it, smearing it, or swallowing it. After unknowable eons of our ancestors randomly sampling the natural landscape, in 1847 the first drug was discovered using a reasonably scientific method of screening. At the time, physicians were using ether as a surgical anesthetic, prompting them to reason that there could be other chemical compounds similar to ether that might work even better. Ether had a few obvious shortcomings—it irritated patients’ lungs and had an unfortunate tendency to explode—so physicians knew there would great clinical value for a new anesthetic without these issues.

    Since ether was a volatile organic liquid, the Scottish physician James Young Simpson and two of his colleagues decided to test every volatile organic liquid they could get their hands on. Their screening process was simple: they opened a bottle of a given test liquid and inhaled its vapors. If nothing happened, they labeled the sample inactive. If they woke up on the floor, they labeled the sample active.

    This screening protocol, of course, would never meet contemporary standards for laboratory safety. Benzene, for instance, is a volatile organic liquid that was widely available at the time and was almost certainly one of the compounds that Simpson screened. We now know that benzene is carcinogenic, and inhaling its vapors can cause long-term damage to your ovaries or testes.

    Despite the recklessness of their screening method, on the evening of November 4, 1847, Dr. Simpson and his colleagues tested chloroform. When the three men inhaled the chemical it produced a mood of cheer and good humor—followed by collapse and unconsciousness. When they awoke hours later, Simpson knew they had identified an active sample.

    Hoping to confirm their findings, Simpson insisted that his niece, Miss Petrie, inhale the chloroform while he watched. The girl blacked out. It is fortunate she woke again, since we now know that chloroform is a powerful cardiovascular depressant, producing a high incidence of death when used as a surgical anesthetic. Despite these dangers, by sniffing chemical after chemical in his living room, Simpson had discovered one of the blockbuster drugs of the nineteenth century—a pharmaceutical origin story unlikely to be duplicated today. But you never know. In the 1980s, I tried to find new drugs in the back of a Volkswagen microbus.

    If you are thinking that I must have been indulging in tie-dyed psychedelic experimentation—after all, why else would anyone be diverting himself with unknown drugs in the back of a lime-green VW bus?—you would be wrong. One of my first paid jobs was working as a drug hunter in an antibiotics discovery group. A common method for searching for new antibiotics is to screen microorganisms living in the soil. I always kept an eye out for new kinds of soil that might hide a pharmaceutical payoff—and a commercial payoff. I was literally looking for pay dirt.

    One weekend, I volunteered to travel to the Delmarva Peninsula to screen soil samples from the Chesapeake Bay side of the peninsula. I took our “mobile laboratory”—the microbus, which we had equipped with a sink and a Bunsen burner. Since my group had recently discovered a new type of antibiotic called monobactams, we christened our mobile laboratory the “Monobacvan.”

    I somehow managed to recruit my wife to come with me with promises of sunbathing on the beach, but then conscripted her into driving the Monobacvan around the tight curves of the rural shoreline as I hunkered down in the back, abruptly ordering her to stop so I could dash out and fill bags full of dirt. During those moments when we were not driving or scooping up the dank, smelly Chesapeake earth, I was diluting the samples and slapping them on Petri plates. My wife was not pleased. The weekend was a bust for both of us, since when I got back to the lab on Monday and we tested my samples, each one turned out to be inactive. My wife informed me that if I did not want my marriage labeled inactive, our next road trip needed much more sunbathing and absolutely no more screening.

    When people learn that I am a drug hunter they usually ask me at least one of the following three questions—usually expressed with some well-founded cynicism:

    Why are my drugs so expensive?

    Why do my drugs have such unpleasant side effects?

    Why is there no medicine for the malady that afflicts me or someone I love?

    The truth of the matter is that the answers to all three are tied to the fact that drug hunting—at least, thus far—is dismayingly difficult because every contemporary method of drug development relies, at some crucial juncture, on trial-and-error screening, just as it did when Neanderthals roamed the wilds. We still do not possess adequate knowledge of human biology to provide us with theories and principles that could rationally guide us to the salubrious molecules we so fiercely desire.

    # # #

    Excerpted with permission from The Drug Hunters: The Improbable Quest to Discover New Medicines by Donald R. Kirsch and Ogi Ogas.



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