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156-915-1 - Accelerated CCSE 1.1 NGX - BrainDump Information

Vendor Name : CheckPoint
Exam Code : 156-915-1
Exam Name : Accelerated CCSE 1.1 NGX
Questions and Answers : 272 Q & A
Updated On : January 16, 2019
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156-915-1 exam Dumps Source : Accelerated CCSE 1.1 NGX

Test Code : 156-915-1
Test Name : Accelerated CCSE 1.1 NGX
Vendor Name : CheckPoint
Q&A : 272 Real Questions

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CheckPoint CheckPoint Accelerated CCSE 1.1

Immunotherapy Advances SCLC medicine panorama | killexams.com Real Questions and Pass4sure dumps

Christine Lee Hann, MD, PhD

Christine Lee Hann, MD, PhD

the new ordinary of take care of the frontline medication of patients with wide-stage small telephone lung melanoma (SCLC) should be atezolizumab (Tecentriq) and chemotherapy, according to consequences from the IMpower133 trial, noted Christine Lee Hann, MD, PhD.

This world, randomized section III trial validated an improvement in survival with the addition of the PD-L1 inhibitor to standard carboplatin and etoposide in patients with huge-stage SCLC versus the chemotherapy routine alone.

After a median follow-up of 13.9 months, the median universal survival (OS) within the experimental arm changed into 12.3 months compared with 10.three months with chemotherapy alone (HR, 0.70; 95% CI, 0.54-0.91; P = .0069). Median progression-free survival (PFS) changed into 5.2 months within the atezolizumab arm compared with 4.3 months in the placebo arm.

within the cohort of 403 remedy-naïve patients, all sufferers obtained four 21-day cycles of carboplatin AUC 5 mg/mL/min intravenously (IV) on day 1 and a hundred mg/m2 etoposide IV on days 1 via three. sufferers were also randomized 1:1 to acquire both concurrent atezolizumab at 1200 mg IV on day 1 (n = 201) or placebo (n = 202) all the way through the induction part. medication become followed with the aid of upkeep therapy with atezolizumab or placebo, in response to the outdated random assignment, every 3 weeks until progressive sickness or loss of clinical advantage.

in addition, single-agent nivolumab (Opdivo) was granted an accelerated FDA approval in August 2018 for the remedy of patients with SCLC with ailment development following platinum-based mostly chemotherapy and 1 different line of therapy, marking the first drug approval in this sickness in well-nigh 20 years.

youngsters, other immunotherapy suggestions haven't shown the equal exercise. as an instance, in the phase III CheckMate-451 trial, the combination of nivolumab and ipilimumab (Yervoy) did not enrich OS versus placebo as a protection remedy for patients with wide-stage SCLC with out ailment development following frontline platinum-based chemotherapy.

In an interview all the way through the 2018 OncLive® on the 2018 State of the Science Summit™ on superior Non–Small phone Lung cancer, Hann, an associate professor of Oncology at Johns Hopkins college of medication, discussed how recent information have fashioned SCLC remedy.

OncLive: What are the recent advances in SCLC remedy? Hann: probably the most most exciting fresh information emerged at the nineteenth World conference on Lung cancer. Stephen V. Liu, MD, offered outcomes from the IMpower133 examine which evaluated first-line chemotherapy in combination with the PD-L1 inhibitor atezolizumab. This turned into the first study in the frontline setting to exhibit better survival benefit; in fact, there was development in PFS and OS in sufferers who obtained the combination. We consider this can now be considered the new average of take care of frontline medicine of this affected person inhabitants. How do you see researchers compounding this statistics for future development? there is a great deal to look forward to. within the last couple of years, we've had an enormous emergence of records both on the organic end and on the clinical facet. We keep in mind the disease improved and we've discovered new agents, reminiscent of checkpoint inhibitors, which have efficacy during this space. The checkpoint inhibitors were effective in the second-line atmosphere and past.

really, nivolumab bought FDA approval in August 2018 in the third-line setting of SCLC; this turned into the first drug approval we had in 2 many years and it turned into an incredible accomplishment in the box. We are actually combinations and new molecular targets during this area.

What are some of those rising molecular pursuits and targeted treatments? there has been a renewed pastime in gaining knowledge of SCLC. Consequentially, there has been improved funding from the national melanoma Institute to assist us keep in mind the sickness more advantageous. [This renewed interest in SCLC] has emerged in parallel with technological advances that enable us to obtain a deep genomic understanding. We are actually in a position to get epigenetic and proteomic profiles of the melanoma. within the remaining 5 years, there has been increasing assistance on the proteins expressed in SCLC that may well be pursuits.

It is going to take a very long time to in reality tease through all these details, however we're relocating in the correct course. SCLC is a melanoma with a very high tumor mutation burden, so there is doubtless a task for combined focused remedies.

what's a closing unmet want in SCLC? There had been only a few studies taking a look at restrained-stage SCLC. whereas there is healing capabilities with chemotherapy and radiation, the substantial majority of sufferers recur locally and distantly. There are reports with immune-checkpoint inhibitors underway in this area, and people [data] could be very constructive. With the encouraging information we saw with durvalumab (Imfinzi) in stage III non–small cell lung melanoma, we consider there is fantastic competencies for previous-line immunotherapy. what's your take-home message to neighborhood oncologists? we have a new common of care for first-line medication of SCLC. numerous reports will also be study out within the subsequent yr or so in an effort to expand our armamentarium even further. we are able to see statistics bearing on the use of checkpoint inhibitors within the upkeep atmosphere, no matter if [they are being used] in aggregate or as single agents. long-term biomarker studies are also standard.

Liu S, Mansfield A, Szczesna S, et al. First-line atezolizumab plus chemotherapy in extensive-stage small-cell lung melanoma [published online September 25, 2018]. N Eng J Med. doi: 10.1056/NEJMoa1809064.


Celldex: What's the entire exhilaration About? | killexams.com Real Questions and Pass4sure dumps

No outcomes discovered, are attempting new keyword!CDX-1127 is an antibody that raises T phone exercise that however a bit differentiated in mechanism of action can be compared to the checkpoint inhibitors Yervoy ... had revenue on $1.1 billion in ...

Bristol-Myers Squibb Receives tremendous CHMP Opinion within the European Union for Opdivo (nivolumab) for the medicine of superior Melanoma in each First-Line and up to now ... | killexams.com Real Questions and Pass4sure dumps

PRINCETON, N.J.--(business WIRE)--Bristol-Myers Squibb business (NYSE:BMY) nowadays announced that the Committee for Medicinal items for Human Use (CHMP) of the european drugs company (EMA) has adopted a favorable opinion recommending that Opdivo (nivolumab), a PD-1 immune checkpoint inhibitor, be granted popularity of use in both first-line and in the past handled sufferers with advanced (unresectable or metastatic) melanoma. here is the primary high-quality opinion given by way of the CHMP for a PD-1 immune checkpoint inhibitor, and it will now be reviewed by the eu fee, which has the authority to approve drugs for the eu Union (ecu).

The EMA granted Bristol-Myers Squibb accelerated evaluation of Opdivo in response to current laws that fulfills its suggestions about “medicinal items of foremost interest from the factor of view of public health and in selected from the view aspect of therapeutic innovation.”

“we are completely satisfied with today’s CHMP fine opinion, as it is a step closer to us bringing this critical drugs for these advanced melanoma sufferers in Europe in want of recent alternate options,” spoke of Michael Giordano, senior vp, Head of construction, Oncology. “Our vision is to seriously change how we method melanoma – from scientific practice to greater patient consequences. We continue to expand the breadth and depth of our immuno-oncology portfolio throughout the continuum of melanoma and assorted other cancers, to provide extra sufferers with the talents possibility for long-time period survival.”

wonderful Opinion according to CheckMate -066, -037

The CHMP wonderful opinion is in line with facts from two part III studies (CheckMate -066 and -037), demonstrating the efficacy and security of Opdivo in advanced melanoma sufferers with vital unmet wants. CheckMate -066, a part III randomized double-blind examine, evaluating Opdivo to the chemotherapy dacarbazine (DTIC) in sufferers with medication-naïve advanced melanoma, is the primary phase III trial of an investigational PD-1 immune checkpoint inhibitor to show an normal survival advantage in advanced melanoma, as well as a stronger purpose response rate. A 2d study, CheckMate -037, is a phase III randomized, controlled open-label study of Opdivo versus investigator’s alternative chemotherapy in sufferers with advanced melanoma who were up to now handled with Yervoy (ipilimumab), which confirmed development in aim response rates. These records are supported by means of a phase Ib look at (study -003) in relapsed superior or metastatic melanoma, which validated the first characterization of Opdivo advantage/chance in advanced melanoma. There was consistent Opdivo dosing of 3 mg/kg every two weeks throughout all three trials.

About Opdivo

Bristol-Myers Squibb has a huge, global development program to analyze Opdivo in assorted tumor forms along with more than 50 trials – as monotherapy or in mixture with other treatments – in which more than 7,000 patients had been enrolled worldwide.

Opdivo became the primary PD-1 immune checkpoint inhibitor to get hold of regulatory approval anyplace on this planet on July four, 2014 when Ono Pharmaceutical Co. announced that it acquired manufacturing and advertising approval in Japan for the medicine of patients with unresectable melanoma. within the U.S., the U.S. meals and Drug Administration (FDA) granted its first approval for Opdivo for the remedy of patients with unresectable or metastatic melanoma and disorder development following Yervoy (ipilimumab) and, if BRAF V600 mutation effective, a BRAF inhibitor. On March 5, 2015, Opdivo recently received its second FDA approval for the treatment of patients with metastatic squamous non-small mobile lung melanoma (NSCLC) with progression on or after platinum-based mostly chemotherapy.

About superior Melanoma

Melanoma is a kind of skin cancer characterized via the uncontrolled boom of pigment-producing cells (melanocytes) observed in the skin. Metastatic melanoma is the deadliest form of the disorder, and happens when melanoma spreads beyond the surface of the dermis to the other organs, such because the lymph nodes, lungs, brain or other areas of the physique. The incidence of melanoma has been increasing for as a minimum 30 years. In 2012, an estimated 232,a hundred thirty melanoma circumstances had been diagnosed globally. Melanoma is in general curable when handled in its early ranges. youngsters, in its late stages, the ordinary survival fee has traditionally been simply six months with a one-yr mortality expense of 75%, making it one of the crucial aggressive types of cancer.

Immuno-Oncology at Bristol-Myers Squibb

surgical procedure, radiation, cytotoxic or targeted healing procedures have represented the mainstay of cancer treatment over the remaining several decades, however lengthy-term survival and a favorable first-class of lifestyles have remained elusive for a lot of sufferers with advanced disease.

To handle this unmet scientific need, Bristol-Myers Squibb is main analysis in an innovative box of cancer analysis and medication called immuno-oncology, which includes agents whose primary mechanism is to work without delay with the body’s immune system to combat cancer. The enterprise is exploring loads of compounds and immunotherapeutic methods for sufferers with several types of melanoma, including learning the potential of mixing immuno-oncology agents that target different and complementary pathways in the remedy of cancer.

Bristol-Myers Squibb is committed to advancing the science of immuno-oncology, with the purpose of changing survival expectations and the way patients are living with cancer.

about the Bristol-Myers Squibb and Ono Pharmaceutical Collaboration

In 2011, via a collaboration contract with Ono Pharmaceutical, Bristol-Myers Squibb improved its territorial rights to boost and commercialize Opdivo globally apart from in Japan, South Korea and Taiwan, where Ono had retained all rights to the compound on the time. On July 23, 2014, Bristol-Myers Squibb and Ono Pharmaceutical additional extended the corporations’ strategic collaboration agreement to jointly boost and commercialize distinctive immunotherapies – as single agents and mixture regimens – for sufferers with melanoma in Japan, South Korea and Taiwan.

vital safety suggestions

Immune-Mediated Pneumonitis

  • extreme pneumonitis or interstitial lung disease, including deadly situations, occurred with OPDIVO medication. across the clinical trial experience in 691 patients with solid tumors, deadly immune-mediated pneumonitis happened in 0.7% (5/691) of patients receiving OPDIVO; no cases happened in Trial 1 or Trial three. In Trial 1, pneumonitis, including interstitial lung disorder, befell in 3.4% (9/268) of sufferers receiving OPDIVO and not one of the 102 patients receiving chemotherapy. Immune-mediated pneumonitis came about in 2.2% (6/268) of patients receiving OPDIVO; one with Grade 3 and 5 with Grade 2. In Trial three, immune-mediated pneumonitis came about in 6% (7/117) of sufferers receiving OPDIVO, including, 5 Grade 3 and two Grade 2 cases. monitor sufferers for indications and signs of pneumonitis. Administer corticosteroids for Grade 2 or greater pneumonitis. completely discontinue OPDIVO for Grade 3 or 4 and withhold OPDIVO unless decision for Grade 2.
  • Immune-Mediated Colitis

  • In Trial 1, diarrhea or colitis passed off in 21% (57/268) of patients receiving OPDIVO and 18% (18/102) of sufferers receiving chemotherapy. Immune-mediated colitis occurred in 2.2% (6/268) of sufferers receiving OPDIVO; 5 with Grade 3 and one with Grade 2. In Trial 3, diarrhea took place in 21% (24/117) of sufferers receiving OPDIVO. Grade 3 immune-mediated colitis occurred in 0.9% (1/117) of sufferers. display screen patients for immune-mediated colitis. Administer corticosteroids for Grade 2 (of greater than 5 days period), three, or 4 colitis. Withhold OPDIVO for Grade 2 or three. completely discontinue OPDIVO for Grade 4 colitis or recurrent colitis upon restarting OPDIVO.
  • Immune-Mediated Hepatitis

  • In Trial 1, there become an accelerated incidence of liver test abnormalities in the OPDIVO-treated group as compared to the chemotherapy-treated group, with increases in AST (28% vs 12%), alkaline phosphatase (22% vs 13%), ALT (sixteen% vs 5%), and complete bilirubin (9% vs 0). Immune-mediated hepatitis took place in 1.1% (3/268) of patients receiving OPDIVO; two with Grade three and one with Grade 2. In Trial three, the incidences of extended liver check values had been AST (16%), alkaline phosphatase (14%), ALT (12%), and complete bilirubin (2.7%). computer screen patients for abnormal liver checks earlier than and periodically all over treatment. Administer corticosteroids for Grade 2 or enhanced transaminase elevations. Withhold OPDIVO for Grade 2 and completely discontinue OPDIVO for Grade 3 or four immune-mediated hepatitis.
  • Immune-Mediated Nephritis and Renal Dysfunction

  • In Trial 1, there turned into an improved incidence of expanded creatinine in the OPDIVO-handled neighborhood as compared to the chemotherapy-treated group (13% vs 9%). Grade 2 or three immune-mediated nephritis or renal dysfunction came about in 0.7% (2/268) of patients. In Trial 3, the incidence of multiplied creatinine turned into 22%. Immune-mediated renal dysfunction (Grade 2) befell in 0.9% (1/117) of sufferers. video display sufferers for increased serum creatinine just before and periodically all over treatment. For Grade 2 or three serum creatinine elevation, withhold OPDIVO and administer corticosteroids; if worsening or no growth happens, permanently discontinue OPDIVO. Administer corticosteroids for Grade four serum creatinine elevation and completely discontinue OPDIVO.
  • Immune-Mediated Hypothyroidism and Hyperthyroidism

  • In Trial 1, Grade 1 or 2 hypothyroidism took place in eight% (21/268) of patients receiving OPDIVO and none of the 102 patients receiving chemotherapy. Grade 1 or 2 hyperthyroidism occurred in three% (8/268) of patients receiving OPDIVO and 1% (1/102) of patients receiving chemotherapy. In Trial three, hypothyroidism passed off in four.3% (5/117) of patients receiving OPDIVO. Hyperthyroidism occurred in 1.7% (2/117) of sufferers, including one Grade 2 case. display screen thyroid function prior to and periodically all through remedy. Administer hormone substitute therapy for hypothyroidism. initiate medical administration for control of hyperthyroidism.
  • other Immune-Mediated hostile Reactions

  • In Trial 1 and three (n=385), right here clinically colossal immune-mediated antagonistic reactions occurred in <2% of OPDIVO-treated patients: adrenal insufficiency, uveitis, pancreatitis, facial and abducens nerve paresis, demyeliniation, autoimmune neuropathy, motor dysfunction, and vasculitis. across scientific trials of OPDIVO administered at doses three mg/kg and 10 mg/kg, extra clinically huge, immune-mediated hostile reactions have been recognized: hypophysitis, diabetic ketoacidosis, hypopituitarism, Guillain-Barré syndrome, and myasthenic syndrome. based on the severity of adverse reaction, withhold OPDIVO, administer excessive-dose corticosteroids, and, if appropriate, provoke hormone- substitute therapy.
  • Embryofetal Toxicity

  • in accordance with its mechanism of action, OPDIVO may cause fetal harm when administered to a pregnant lady. recommend pregnant women of the knowledge risk to a fetus. advise ladies of reproductive skills to make use of valuable contraception all over medication with OPDIVO and for at least 5 months after the ultimate dose of OPDIVO.
  • Lactation

  • It is not established even if OPDIVO is present in human milk. as a result of many medicine, together with antibodies, are excreted in human milk and because of the abilities for critical opposed reactions in nursing toddlers from OPDIVO, advise girls to discontinue breastfeeding throughout medicine.
  • severe opposed Reactions

  • In Trial 1, critical hostile reactions occurred in forty one% of patients receiving OPDIVO. Grade three and 4 opposed reactions came about in forty two% of patients receiving OPDIVO. probably the most usual Grade 3 and four opposed drug reactions pronounced in 2% to <5% of patients receiving OPDIVO have been abdominal pain, hyponatremia, multiplied aspartate aminotransferase, and increased lipase.
  • In Trial three, severe adversarial reactions occurred in 59% of sufferers receiving OPDIVO. the most regularly occurring critical adverse drug reactions pronounced in ≥2% of sufferers were dyspnea, pneumonia, persistent obstructive pulmonary sickness exacerbation, pneumonitis, hypercalcemia, pleural effusion, hemoptysis, and pain.
  • usual adversarial Reactions

  • essentially the most commonplace adverse reactions (≥20%) mentioned with OPDIVO in Trial 1 had been rash (21%) and in Trial three have been fatigue (50%), dyspnea (38%), musculoskeletal ache (36%), lowered appetite (35%), cough (32%), nausea (29%), and constipation (24%).
  • Please see US Full Prescribing guidance for OPDIVO.

    About Bristol-Myers Squibb

    Bristol-Myers Squibb is a global pharmaceutical company whose mission is to find, enhance and carry innovative drugs that aid patients be triumphant over critical ailments. For more advice about Bristol-Myers Squibb, seek advice from www.bms.com, or comply with us on Twitter at http://twitter.com/bmsnews.

    Bristol-Myers Squibb ahead-looking statement

    This press free up consists of "forward-searching statements" as that term is described within the inner most Securities Litigation Reform Act of 1995 concerning the research, construction and commercialization of pharmaceutical items. Such ahead-looking statements are in keeping with present expectations and contain inherent risks and uncertainties, including components that might delay, divert or change any of them, and will trigger actual results and results to vary materially from existing expectations. No forward-looking commentary may also be guaranteed. amongst other risks, there can also be no guarantee that Opdivo will acquire regulatory approval in the European Union or, if accredited, that it will become a commercially a success product. forward-searching statements during this press free up should be evaluated along side the various uncertainties that affect Bristol-Myers Squibb's business, mainly these identified in the cautionary elements discussion in Bristol-Myers Squibb's Annual document on kind 10-okay for the 12 months ended December 31, 2014 in our Quarterly stories on form 10-Q and our existing reports on kind 8-okay. Bristol-Myers Squibb undertakes no obligation to publicly update any ahead-searching commentary, whether on account of new advice, future events or otherwise.




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    With New Turing, NVIDIA Doubles Down on the Future of Real-Time Ray-Tracing | killexams.com real questions and Pass4sure dumps

    18 Oct, 2018 By: Alex Herrera Herrera on Hardware: CAD professionals are expected to reap the benefits.

    NVIDIA's long-expected successor to its Pascal GPU architecture for gaming and professional graphics is here. In August, the GPU developer pulled the covers off Turing, which one could argue is both a successor to not one but both of its preceding generations of graphics processing units — 2016's Pascal and 2017's Volta. In the process, the company confirmed several of the more expected 3D graphics advancements for its next flagship GPU. But it also revealed a few surprises, representing an aggressive-but-justified departure from past generations' decisions about how it formulates products that today are destined for a far wider spectrum of applications than those of years past.

    Perhaps even more significant is the inflection point in GPU evolution that Turing marks, a unification — if not permanent and all-encompassing, at the very least meaningful — of the previous disparate and often conflicting priorities between the GPU's traditional 3D graphics markets and the hot emerging opportunities attracting the company's attention. With Turing, NVIDIA confirms two realizations very much reflected in the GPU's DNA: one, that machine learning is now a valid and justified tool to enhance 3D visual computing; and two, that the time is ripe to begin the long-awaited transition from 3D raster graphics to the ultimate in rendering, real-time ray-tracing.

    Turing, RTX, and NGX

    NVIDIA is finding more ways to leverage machine learning to improve performance and quality for traditional 3D graphics. It's been a while since NVIDIA shaped new GPU architectures and technology strictly for the benefit of traditional raster-based 3D graphics that CAD applications and users have primarily relied upon. Over the past decade, NVIDIA GPUs have pushed well beyond that core space and into high-performance computation ("compute"), autonomous vehicles, robotics, supercomputing, and now, front-and-center, machine learning. And each new generation has walked a careful balance, supporting new applications without handicapping the GPU for its bread-and-butter 3D graphics markets.

    With Turing, NVIDIA made many of the more conventional improvements to its fundamental 3D graphics programmable shader engine, the Streaming Multiprocessor (SM), especially in terms of critical resources like chip registers and cache, and dialed up supporting infrastructure including external memory bandwidth — all good things that contribute to faster, higher-quality interactive 3D graphics crucial to improving the CAD experience and productivity. But those tweaks represent the more expected steps along the tried-and-true GPU evolution path, taking on cost and complexity for features and performance the company is pretty darn sure ISVs and end users alike will value in the near term, if not immediately. More noteworthy than the more conventional 3D graphics features Turing added is what it didn't subtract from the company's previous compute/artificial intelligence (AI)–focused GPU, Volta. With Turing, NVIDIA architects not only didn't strip out Volta's Tensor Cores, they improved on them — and doubled down on the pursuit of real-time rendering by boosting ray-trace-specific acceleration.

    Tensor Cores accelerated AI for ray-tracing — and now they speed conventional 3D raster graphics to boot. Volta's most noteworthy advancement was the inclusion of Tensor Cores, new hardware engines — of significant incremental chip cost (i.e. transistors/silicon area) — to accelerate processing of deep neural networks (DNNs), the lifeblood of machine learning applications. Now, given Volta's primary focus on high-performance computing rather than 3D graphics, the choice to take on the silicon cost of Tensor Cores was certainly novel, but not particularly contentious.

    But unlike Volta and its compute focus, Turing is a graphics-first architecture, so NVIDIA's decision to keep Tensor Cores in Turing raises a very pertinent question: Why would the company dedicate significant cost in a graphics-focused GPU to a feature that doesn't directly benefit graphics? Well, the answer is most interesting and fortunate: That old premise is no longer true, and NVIDIA is now finding compelling ways to leverage machine learning to improve the quality and performance of 3D imagery.

    As discussed in detail in a previous column, "What Does NVIDIA's Ray Tracing News Mean for the CAD Market?" NVIDIA figured out a way to leverage deep learning to significantly improve the performance of ray-traced 3D rendering. Specifically, RTX software exploits Tensor Core hardware incorporated in a DNN in the ray-tracer to accelerate image "convergence" by decreasing the computational load in the latter stages of rendering. Once the image converges into something it can recognize, AI fills in remaining rays/pixels, intelligently de-noising the image and wrapping up the time-consuming rendering process far faster than is possible via exhaustive, full-resolution ray processing.

    RTX technology on Volta (right side) accelerates ray-tracing through machine learning. (Source: NVIDIA)RTX technology (right side) accelerates ray-tracing through AI-accelerated de-noising, compared with the same number of rays without de-noising (left).  (Source: NVIDIA)

    No doubt enthused by the successful synergy of machine learning and graphics with ray-trace processing, NVIDIA researchers began exploring other ways to extract more visual processing goodness out of its GPUs' AI prowess. Extending on the use of DNNs for ray-trace de-noising, NVIDIA unveiled NGX technology, comprised of an expanded set of DNN-driven image-enhancement features.

    The most relevant and compelling example using Turing/NGX to enhance conventional 3D graphics is Deep Learning Super Sampling (DLSS). Essentially, DLSS benefits from a Tensor Core–accelerated DNN that substitutes the usual brute-force pixel super-sampling with intelligent choices based on the scene geometry, and based both on one frame instance and interframe temporal changes. The benefit is that quality improves at the same performance level, or likely more interesting for most applications (because resolution-dependent quality is pretty darn good at this point), performance increases significantly at the same quality level. I have no doubt NVIDIA sees NGX today as anything but a fixed set of features, but rather an evolving and expanding toolbox of DNNs that can further harness machine learning for the benefit of NVIDIA's traditional visual markets as time goes on.

    AI-enabled DLSS anti-aliasing: There’s great value in any GPU feature that can deliver the same quality in fewer cycles. (Source: NVIDIA)AI-enabled DLSS anti-aliasing: There's great value in any GPU feature that can deliver the same quality in fewer cycles. (Source: NVIDIA)

    And NVIDIA Doubles Down with RT Cores

    Not only did NVIDIA preserve those Tensor Cores when creating Turing, it took the further step of adding multiple instances (one per SM) of an entirely new core design: the RT Core. Specifically, the RT Core takes on a critical ray-tracing computing task, one that when executing on previous GPUs' SMs proved cumbersome, inefficient, and time-intensive. Determining whether a ray (shot from a viewport out into the scene) actually intersects an object (and which triangle on that object's surface) is one of those tasks that a traditional raster-based 3D shader wasn't designed to do, and therefore doesn't do particularly well. With Turing, that job is now left to the RT Cores, freeing up the SMs to spend cycles instead on the 3D shader processing they're more adept at executing.

    Turing’s Streaming Multiprocessor with RT Core. (Source: NVIDIA)Turing's Streaming Multiprocessor with RT Core. (Source: NVIDIA)

    What's the internal micro-architecture of the RT Core look like? Well, NVIDIA hasn't exposed the guts, but given its task — a lot of 3D geometry processing — there's little doubt some high-performance vector and matrix floating-point units form its foundation. What NVIDIA has disclosed is the performance of the RT Core: 10 GigaRays/second. Now, in absolute terms, that's a hard number to assess — like triangles/second in the rasterization world — as it all depends on the workload of each ray measured. The more relevant, apples-to-apples comparison is that rate relative to Pascal's 1.1 GigaRays/second, presumably of the same workload per ray. Given that, Turing is packing a 10X performance improvement processing a crucial and demanding portion of the ray-tracing pipeline.

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    Intercontinental Exchange's (ICE) CEO Jeff Sprecher on Q4 2017 Results - Earnings Call Transcript | killexams.com real questions and Pass4sure dumps

    No result found, try new keyword!ICE’s consolidated fourth quarter net revenues increased 1% to $1.1 billion. Data revenues increased 2% as reported ... including the Bank of America/Merrill Lynch indices, Euroclear, NGX and BondPoin...


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