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1Z0-872 - MySQL 5 Developer Certified Professional(R) Part II - BrainDump Information

Vendor Name : Oracle
Exam Code : 1Z0-872
Exam Name : MySQL 5 Developer Certified Professional(R) Part II
Questions and Answers : 70 Q & A
Updated On : November 16, 2018
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1Z0-872 exam Dumps Source : MySQL 5 Developer Certified Professional(R) Part II

Test Code : 1Z0-872
Test Name : MySQL 5 Developer Certified Professional(R) Part II
Vendor Name : Oracle
Q&A : 70 Real Questions

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Oracle Oracle MySQL 5 Developer

Now an Oracle product, what occurs to MySQL? | killexams.com Real Questions and Pass4sure dumps

Attendees at the open supply database's annual builders' convention in Santa Clara this morning are waking as much as the astonishing news that their personal product, whose value to solar Microsystems became to have been lauded by using none apart from sun co-founder Andreas von Bechtolsheim in a keynote handle scheduled for Thursday, is now owned through Oracle programs.

The preliminary cost of MySQL to Oracle -- up until this morning, its largest competitor -- became evident through its absence from this morning's joint press conference that includes solar and Oracle executives. solar CEO Jonathan Schwartz outlined MySQL together with OpenOffice as part of what he now calls the world's largest supplier for open supply application. unless Oracle's SEC filings are made public, we won't know even if MySQL even factored into its valuation of sun.

LinuxQuestions.org editor Jeremy had, well, Linux questions this morning after the information turned into introduced: "With a great deal of sun's revenue coming from hardware, will [Oracle] spin that division off or use it to center of attention extra on a complete Oracle stack, that comprises every little thing from hardware to database?" Jeremy wrote. "moving to the individual constituents of that stack, will Oracle proceed with the SPARC CPU line or be drawn to the extra commodity x86 traces? at the OS degree, will Oracle continue to focus on Linux and their Unbreakable implementation or will they try and hold Solaris alive? Oracle has been contributing to Linux in a major means lately, and it will be an incredible loss for that to go away."

unbiased analyst and Betanews contributor Carmi Levy believes the deal might allow some exciting alternatives for Oracle, which in past times has had more issue breaking into the lessen conclusion of the database market. There, MySQL guidelines among open source users, and Microsoft SQL Server has had a stronghold among the commercial set.

"This thinking extends into the lower conclusion of the market as well, given how the sun acquisition gives Oracle entry to MySQL," Levy advised Betanews. "while no person might ever rightfully claim that MySQL threatens Oracle's better-conclusion database choices, its addition to the portfolio offers Oracle additional leverage in a market with huge growth knowledge. The MySQL put in base of approximately 11 million offers Oracle income groups fertile opportunity to have conversations they have not prior to now had."

but MySQL's aid base is comprised in tremendous half via impartial builders, and that is the reason via design. Already, those independent builders are waking up to a new world, together with software engineer Ryan Thiessen. An 11-12 months MySQL veteran, Thiessen is scheduled to speak at the MySQL convention this week; and in a weblog put up this morning entitled conveniently, "stunned," he exhibits his bewilderment:

"last time this 12 months i was cautiously confident about sun's purchase of MySQL. but not this 12 months -- it's worry and disappointment over what this ability for MySQL," Thiessen wrote. "once I examine this as a rumor a number of weeks in the past i assumed it changed into a joke of a concept. Why would a excessive margin utility enterprise want to buy a declining hardware enterprise, even though that hardware is high-quality? As for their utility, I can't think about that Oracle is attracted to Java, MySQL, and so on as earnings producing products, it could simply be a tiny blip for them."particularly, Java and Solaris were outlined by Oracle CEO Larry Ellison because the key motivating factors, not the SPARC enterprise -- definitely, it changed into SPARC that did not generate a blip. MySQL received at the least that plenty -- this for a enterprise that changed into value at the least a thousand million to solar just 15 months in the past.

MySQL's founders have remained on the checklist as fiercely against using application patents, as dangerous to the spirit and ethics of open source. Oracle is not diametrically opposed to that line of considering, having made statements in principle all the way through this decade opposing the advent of patent portfolios for predatory purposes.

Oracle's 2000 statement on the situation, which is essentially unchanged, reads, "Patent legislation gives to inventors an exclusive right to new know-how in return for ebook of the expertise. here's now not appropriate for industries equivalent to utility building by which innovations take place hastily, can be made with out a considerable capital investment, and tend to be creative mixtures of previously-primary ideas."

however Oracle does help using patents for defensive applications, certainly when an organization is attacked by a corporation with a large portfolio.That reality on my own doesn't mean Oracle cannot, or hasn't, used its software belongings very aggressively. In October 2005, the business bought its first usual open source database component: Innobase, whose InnoDB contained enterprise-type features that have been in fact rolled into MySQL 5.0. by using acquiring InnoDB, Oracle ended up possessing a part of MySQL anyway, in a move that InfoWorld's Neil McAlister astutely reasoned may be to preserve the lessen-category database snugly within the lower classification, whereas siphoning valued clientele into Oracle's higher class.

"it's why when Oracle snapped up Innobase in early October it become easy to interpret the movement as a big offensive on Oracle's half," McAlister wrote then. "via taking handle of one of MySQL's a must-have internal organs, Oracle positive aspects the vigor to crush the upstart at a whim, with ease through closing its grip round Innobase. but, seriously, why would Oracle do that?"

four years later, we have a closer glimpse of a solution to McAlister's question: by using taking handle of the geography of commercial enterprise databases over a larger area, Oracle continues MySQL safely within its own continent, both locked away or funneling new shoppers across the channel. might be no one may ever rightly claim that MySQL became a genuine danger, however these days, Oracle's move ensures that it not ever may also be. and that's the reason the brand new world that developers in Santa Clara are waking as much as.


Oracle Developer Cloud to Automate Database Cloud construction | killexams.com Real Questions and Pass4sure dumps

This weblog is the primary within the collection of blogs for the use of Oracle Developer Cloud for Database Cloud carrier automation. during this weblog, we would be focusing on the usage of the Developer Cloud and PaaS service supervisor aka PSM CLI integration within the construct step to create and manage Database Cloud service.

in regards to the weblog collection

As part of the Database Cloud service building and deployment automation, spinning up the PaaS provider and getting ready for Database linked development, it might be part of the DevOps endeavor for database. This weblog sequence would include automation for managing the DBCS lifecycle, automating APEX application workspace management and constructing the APEX utility.

what's PSM CLI?

Oracle PaaS service supervisor (PSM) provides a command line interface (CLI) with which you can manipulate the lifecycle of quite a few services in Oracle Public Cloud. The CLI is a thin wrapper over PaaS relaxation APIs that invokes these APIs to support average PaaS facets; as an instance, creating and managing cases for Oracle Java Cloud provider, Oracle Database Cloud carrier circumstances, and Oracle MySQL Cloud carrier or creating and managing applications with Oracle application Container Cloud service. The CLI additionally supports Oracle Cloud Stack manager, a PaaS device that automates the provisioning and deletion of cloud environments.

Why can we want PSM CLI for Database?

records is vital part of every utility development and consequently is the database. So when we focus on DevOps it would also include creation and configuration of the database PaaS service instance as a vital part of the DevOps. Having this piece of DevOps computerized in our CI & CD pipeline would go along method in decreasing the Ops effort, making software lifecycle management extra effective and effective.

PSM CLI as part of CI & CD

PSM CLI for Database Cloud service example lifecycle management can also be built-in in the CI, CD pipeline with the support of Oracle Developer Cloud carrier. where you will have to create a JSON payload defining the Database Cloud service illustration parameters and then use the Developer Cloud build job to execute a PSM command to create and manipulate the Database Cloud provider instance.

Pre-Requisites

1. access to Oracle Developer Cloud provider

2. access to Oracle Database Cloud provider

3. entry to Oracle Storage Cloud carrier

four. textual content Editor put in on the developer computing device to create/edit JSON payload file.

JSON Payload:

The JSON payload created has to be uploaded to a Git repository on Oracle Developer Cloud provider. For this, you are going to first must create the JSON payload file as below. You might also name it as per your option. For this weblog I actually have named it as create_db.json.

"serviceName": "PSMDB", "version": "EE_HP", "level": "PAAS", "vmPublicKeyText": "ssh-rsa AAAAB3NzaC1yc2EAAAABJQAAAQEAmiJLlEoUzMUXmSFGZpVaRzuuNKEiXEqo5kY/fyqIHsBKC1nNasoMQ1eoa3mwBWkcE6VBD/0EDIfM8JJgOtpL6ivIduBy/x9Zkq9dOUCu61SGFXZ54wirVTxwj/hfLkqjIloTotvM8W4a1hF5dOs0T5NoD1u03pv4vDGTc8c2PPNDkTVzMSVjHnByipBS9YNJcbN1XE9PxdSeTW0Pz/86f7AumzVqTBa3zg8wDJYB0JoHeV2wqZJ46L7iRtnk02d8rNmqO1PUmxmJr0VDF8TpU/JecvSM6HsTHJDfil1v+cx0h/c/VRbt032gZZM7xPiXftqR2Q+YxRTZD/sTzJubVw== rsa-key-20171106", "description": "DB Cloud provider illustration", "subscriptionType": "month-to-month", "form": "oc3", "version": "12.1.0.2", "trial": "false", "parameters": [ "sid": "ORCL", "adminPassword": "******", "backupDestination": "BOTH", "cloudStorageContainer": "Storage-paas124/JcsDBBackup", "cloudStorageUser": "abhinav.shroff@oracle.com", "cloudStoragePwd": "******", "type": "db", "totalDataFileStorage": "88.5", "usableStorage": "25", "failoverDatabase": "no" ]

JSON Payload — explanation

beneath is the explanation for every attribute within the above JSON payload:

1. serviceName — it's the Database Cloud carrier name that we need to provide.

2. version — there are three alternative here, commonplace version (SE1), commercial enterprise edition (EE), business version- excessive performance (EE_HP), commercial enterprise version — excessive performance (EE_EP)

3. degree — it could be ‘PAAS’, the other choice could be virtual photograph.

4. vmPublicKeyText — may also be generated using Puttygen an open source tool for producing ssh key.

5. description — to explain the Database Cloud service illustration that is being created

6. subscriptionType — It can also be ‘month-to-month’ or ‘HOURLY’.

7. form — It describes the compute infrastructure we desire for the Database Cloud carrier. The shape given in the above payload, oc3 describes 1 ocpu and seven.5 GB of Ram. below is the list of options for values that will also be given for the ‘form’ attribute in the payload.

eight. edition — This attribute describes the database version for the Database Cloud carrier we're about to create. here we have3 options: 12.1.0.2, 12.2.0.1 and eleven.2.0.4

9. trial — if it is now not a trial illustration then give false because the cost else it could be proper.

10. parameters –

sid — Database SID identify, it is “ORCL” for this weblog.

adminPassword — Admin password defined for the Cloud Database instance that we intend to create.

backupDestination — This attribute is getting used to define the database backup destination where

we've options such as “each”, “CLOUD” and “NONE”.

cloudStorageContainer — You deserve to define the storage container as beneath. The storage container should exist on the Oracle Storage Cloud carrier illustration you plan to use, else the PSM command to create the database service will now not work.

Storage-<domain identify for the storage provider>/<storage container identify>

cloudStorageUser — Oracle Storage Cloud provider person identify to access the container described above.

cloudStoragePwd — Oracle Storage Cloud carrier password to access the container described above.

category — “db”,

totalDataFileStorage — total records file storage in GBs

usableStorage — Usable storage dimension in GBs

failoverDatabase — If the database don't need to be initialized from a file backup then the value given for this attribute needs to be “no”, else it might be “sure”. In case it is being initialized from backup , then there ought to be few different attributes that need to be added.

This JSON payload which is saved because the create_db.json file, is uploaded to the Git repository hosted on Oracle Developer Cloud provider. beneath display shot depicts it.

in case you are new to Git, under are the Git instructions which can be used with the Git cli.

git init

git add <filename>

git commit -m “<comment>”

git remote add starting place <git repo url>

git push foundation <branch name>

that you can choose to use the same repository to store different PSM related payload information and consolidate all payload JSONS within the equal repository. whereas that you can still choose to have distinctive build jobs gaining access to this repository to execute diverse PSM instructions.

build Configuration

under are the build job configuration monitor photographs for the PSMDBBuild so as to execute the PSM command.

give a name of your option to the construct job. For this blog I actually have named it as ‘PSMDBBuild’. As here is for PSM CLI which you could go away the JDK to default.

choose the repository in which the JSON payload file has been uploaded.

we would be the use of the PSMCli in the construct step to configure the credentials to use PSMCli for the cloud service area that we want to use to create the Database Cloud carrier. along with the PSMCli we can also use the execute shell, where we might execute the PSM command to create the database.

First two instructions in Execute Shell are best for demonstration purpose to see the PSM CLI edition and to list the database features in the domain. You may also decide to run the third command handiest, to create the database provider the usage of the create_db.json payload file which we uploaded to the Git repository configured in the construct job.

beneath is the console output in Developer Cloud carrier. The execution of the command, submits the job for the provider advent. it will take some time earlier than you see the service created within the Database Cloud service console.

as soon as the carrier is created, you see it on the Database Cloud provider console.

There are a lot of other PSM commands that can also be used, as described in the hyperlink under, to manipulate the lifecycle of the Database Cloud carrier using PSM CLI.

https://doctors.oracle.com/en/cloud/paas/java-cloud/pscli/dbcs-create-service.html

happy Coding!

**The views expressed in this put up are my own and do not necessarily mirror the views of Oracle


Framework & Language — proper 5 things for software builders to agree with in SaaS | killexams.com Real Questions and Pass4sure dumps

SaaS (application-as-a-provider) development has evolved tremendously during the last decade. typical laptop functions flow to the cloud, and iterate sooner because of the restrained nature of supported contraptions and open-source utility teams have to hold.

desktop functions can now be overcome readily with the adoption of the open-source Electron framework, wrapping round a hosted SaaS answer.

here’s the record of the right 5 issues technical groups should still accept as true with before bootstrapping their personal SaaS utility.

1. Low-stage Technical StackWould a SaaS work improved in case you select Java, Ruby, php, or C#? Is MySQL a far better opt for than Oracle or Postgres?

The marketing strategy of your product will factor you in opposition t the right technical stack. in case you plan to integrate with average Microsoft items like SharePoint, an ASP.net MVC answer running on suitable of MSSQL may well be the right healthy. Relying heavily on laptop discovering may additionally justify beginning your product with Python.

2. robust and correct FrameworkAside from the core basis, starting to be a excessive-scale product is contingent on defining the appropriate coding necessities, which usually ends up with a flamed dialogue on application frameworks.

often discussed in parallel with the appropriate language or database dialog, picking out a suitable framework can keep time, ensure balance because of a decrease percentage of regressions, cut back the technical debt over time, and ease the transition across boom phases with fewer senior developers on board.

It’s value noting that diverse frameworks and systems have definite strengths that you simply may additionally leverage.

AI-pushed functions that don’t fit smartly into MVC may additionally trust Django, a reputable Python framework following a model-Template-View design architecture, supporting diverse databases with distinct drivers, and scaffolding an outstanding and flexible admin dashboard.

rapid development groups may additionally decide upon Ruby on Rails for its widely wide-spread “convention over configuration” mission commentary. commercial enterprise-grade engineers who want steadiness and security over performance regularly rely on the Java ecosystem and its giant suite of frameworks like JSF, Spring and Struts.

Requiring certain paradigms comparable to parallelization, multithreading, and microservices will turn the scales to a few frameworks frequent for managing such instances smartly sufficient.

as an instance, I’ve developed several SaaS applications on good of WordPress. WordPress may additionally no longer look like a suitable (or scalable) option for SaaS, however I’ve seen it perform smartly due to its Multisite function, or the skill to spin up new subsites within a network, sharing the identical code base however distinct database tables. This makes billing and membership plan administration extremely smartly isolated and manageable ultimately. other tech agencies i know of have picked Laravel Spark for a similar reason, offloading billing or invoicing to a separate package built with the aid of the founding father of Laravel himself.

3. Agility vs. StabilityBuilding a a success SaaS company could be a dash or a marathon. short Agile sprints require fast building innovations, whereas slow and cumbersome stacks may additionally not be a great healthy. then again, rebuilding your whole stack simply in case you hit a first-rate point out on TechCrunch and Mashable because of efficiency leaks may additionally very well break your whole manufacturer.

here's why successful SaaS architects accept as true with frameworks that support them iterate quickly whereas being able to address big volumes of site visitors and facts further down the street.

four. Recruitment and R&D OpportunitiesFast-starting to be startups have to rent and onboard straight away with a purpose to scale. but what if your local market lacks the skill you need?

Perl may well be an outstanding language for parsing typical expressions and managing hashes, but how many Perl engineers work to your metropolis? and the way typical it is for a seasoned developer to pick a job as a Perl developer?

same goes for bleeding-aspect languages and frameworks. If Dart or Go appear to be a fine alternative, feel twice about their adoption and toughness. You can be considered one of their early adopters (and success studies) nonetheless it’s a gamble that can also affect your long-term increase. sure, some banks are commonly used to run construction code on COBOL and Fortran, however’s not like fresh graduates are demise to land a job as COBOL developers at the moment.

5. investment and Exit GoalsFueling your SaaS may additionally require external traders. And aiming for a successful exit capacity that your codebase matters, too.

On one hand, deciding upon a hot language or a framework could be a set off for angel buyers or time-honored engineering VCs to wager on your startup. but it surely’s a difficult bet. also, settling on a truly exciting technical stack may additionally make you less constructive to certain companies drawn to buying a similar enterprise.

LinkedIn turned into developed on suitable of .web and Microsoft received it. Would Microsoft take over LinkedIn and keep funding it if it became developed on Java, its frequent nemesis in the business development house?

Your funding and exit desires should still align with your technical stack.




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Sage Therapeutics Announces Third Quarter 2018 Financial Results and Highlights Pipeline and Business Progress | killexams.com real questions and Pass4sure dumps

CAMBRIDGE, Mass.--(BUSINESS WIRE)--Nov 6, 2018--Sage Therapeutics, Inc. (NASDAQ: SAGE), a clinical-stage biopharmaceutical company developing novel medicines to treat life-altering central nervous system (CNS) disorders, today reported business highlights and financial results for the third quarter ended September 30, 2018.

“At Sage, our approach to scientific discovery and development is focused on transforming the lives of people with life-altering CNS disorders. Our first program, in PPD, exemplifies this philosophy. Members of the PPD patient advocacy community and healthcare providers across the country have shared their sense of urgency with us – they are seeking a new way of thinking about PPD and an opportunity to rapidly alleviate suffering from this condition. If approved, ZULRESSO has the potential to meet these needs and to be an important new tool that healthcare providers can use to ease the burden of PPD for patients and their families,” said Jeff Jonas, M.D., chief executive officer of Sage. “Sage is committed to helping women diagnosed with PPD access ZULRESSO, if it is approved. We are currently assessing potential patient support options to help lessen financial barriers to access for women with PPD in need of treatment, where appropriate and permitted. We aspire to define a new normal for brain health and we’re just getting started.”

ZULRESSO™ (brexanolone) Injection Regulatory and Pre-Launch Activities Updates:

On November 2 nd, the U.S. Food and Drug Administration (FDA) Psychopharmacologic Drugs Advisory Committee (PDAC) and Drug Safety and Risk Management Advisory Committee (DSaRM) jointly voted (17 yes, 1 no) that data support the favorable benefit-risk profile of ZULRESSO™ (brexanolone) injection for the treatment of postpartum depression (PPD) when administered by qualified staff in a facility that has been certified under a Risk Evaluation and Mitigation Strategies (REMS) program. The joint committee based their joint recommendation on the safety and efficacy data from three placebo-controlled clinical studies.The New Drug Application (NDA) for ZULRESSO for the treatment of PPD has been accepted for Priority Review by the FDA. The FDA has assigned a Prescription Drug User Fee Act (PDUFA) target date of December 19, 2018.If approved, ZULRESSO is expected to be scheduled by the U.S. Drug Enforcement Administration (DEA), consistent with other approved GABAergic therapies. The DEA is required to issue an interim final rule controlling the drug within 90 days of approval.Preparations continue for a potential U.S. commercial launch of ZULRESSO for the treatment of PPD in late March 2019, if the NDA is approved and post-DEA scheduling.Sage is continuing discussions with the European Medicines Agency (EMA) to determine the European regulatory pathway for a marketing authorization application (MAA) filing for brexanolone injection for PPD. Sage plans to seek additional Scientific Advice to help determine what additional data or information will be needed prior to filing, as is permissible under the PRIority MEdicines (PRIME) designation program.

Pipeline Updates:Beyond ZULRESSO, Sage is advancing a portfolio of novel CNS product candidates targeting the GABA and NMDA receptor systems. Dysfunction in these systems is known to be at the core of numerous psychiatric and neurological disorders.

SAGE-217 in Major Depressive Disorder (MDD) and PPD: PPD Phase 3 trial enrollment completed: Enrollment was recently completed for the Phase 3 placebo-controlled trial evaluating SAGE-217 in patients with PPD, and Sage plans to announce top-line results in January 2019.MDD Phase 3 trial initiated: Plans are on-track for enrollment to begin in a Phase 3 placebo-controlled trial of SAGE-217 in MDD in 4Q 2018. The trial will evaluate the potential of episodic treatment through a protocol including two weeks of 20mg or 30mg SAGE-217 treatment compared to placebo in approximately 450 patients with MDD, with four weeks of additional follow-up.Long-term retreatment study: Additional data regarding patient safety and potential treatment of recurrent or new major depressive episodes will be acquired through a long-term retreatment study evaluating SAGE-217 treatment and episodic retreatment as needed.SAGE-217 in Other Psychiatric Indications: Bipolar depression: Dosing of patients is underway in Part A of a two-part Phase 2 clinical trial evaluating open-label SAGE-217 treatment in up to 30 patients with bipolar I/II disorder with a current major depressive episode. If Part A is successful, the Company plans to progress to a randomized, placebo-controlled Part B study. The Part A trial is intended to evaluate the safety and tolerability of SAGE-217 and secondary endpoints, including efficacy in improving depressive symptoms and sleep. The top-line results from Part A are planned to be announced in 1H 2019.Sleep disorders: Additional data from a placebo-controlled trial in a model of insomnia demonstrating an encouraging impact of SAGE-217 on sleep architecture was recently presented at the 31 st European College of Neuropsychopharmacology Congress. Sage plans to initiate a Phase 3 placebo-controlled polysomnography trial of SAGE-217 in MDD patients with co-morbid insomnia in 4Q 2018, and also plans to seek feedback in 2019 from the FDA on potential development plans for SAGE-217 for the treatment of sleep disorders and other indications.SAGE-324 in Neurological Indications: Phase 1 program: A Phase 1 single-ascending dose trial of SAGE-324 in healthy volunteers, which is intended to evaluate the safety, tolerability, pharmacokinetic and pharmacodynamic profile of SAGE-324, is ongoing, and Sage plans to complete this trial in 4Q 2018. Based on initial findings from this trial, Sage plans to initiate a Phase 1 multiple-ascending dose trial of SAGE-324 in healthy volunteers in 4Q 2018. SAGE-324 is being developed as a potential treatment for patients impacted by neurological conditions such as epileptiform disorders, essential tremor, and Parkinson’s disease.NMDA Programs: SAGE-718: The healthy volunteer portion of the Phase 1 multiple ascending dose trial of SAGE-718 has been completed. As part of the Phase 1 program, Sage has initiated target engagement biomarker studies, focusing on electrophysiology and imaging, to evaluate SAGE-718 in healthy volunteers, and is considering plans to evaluate the safety, tolerability, pharmacokinetic and pharmacodynamic profile of SAGE-718 in a patient cohort.SAGE-904 is currently in IND-enabling studies.

Expected Milestones

Trial Enrollment Initiations:SAGE-217 Phase 3 placebo-controlled trial in MDD (4Q 2018)SAGE-217 Phase 3 placebo-controlled polysomnography trial in MDD patients with co-morbid insomnia (4Q 2018)SAGE-324 Phase 1 multiple ascending dose trial (4Q 2018)Data Readouts:SAGE-217 Phase 3 placebo-controlled trial in PPD (January 2019)SAGE-217 Phase 2 trial in bipolar depression (1H 2019)SAGE-718 Phase 1 target engagement studies (1H 2019)SAGE-324 Phase 1 multiple ascending dose trial (1H 2019)Regulatory and Commercial:ZULRESSO in PPD PDUFA target date (December 19, 2018)ZULRESSO in PPD commercial launch, if approved (late March 2019)

Financial Results for the Third Quarter of 2018

R&D Expenses: Research and development expenses were $75.1 million, including $14.0 million of non-cash stock-based compensation expense, in the third quarter of 2018, compared to $58.3 million, including $5.4 million of non-cash stock-based compensation expense, for the same period of 2017. The increase in R&D expenses was primarily due to increases in expenses related to ongoing R&D programs and discovery efforts focused on identifying new clinical candidates and additional indications of interest and investments in R&D headcount to support the growth in Sage's pipeline and operations, offset by decreases in expenses due to the completion of Phase 3 clinical development of ZULRESSO.G&A Expenses: General and administrative expenses were $53.7 million, including $11.5 million of non-cash stock-based compensation expense, in the third quarter of 2018, compared to $16.1 million, including $4.3 million of non-cash stock-based compensation expense, for the same period of 2017. The increase in G&A expenses was primarily due to the increase in personnel-related expenses, professional fees to support expanding operations, costs related to continued preparations for a potential commercial launch, and facilities-related costs to support expanding operations.Net Loss: Net loss was $122.9 million for the third quarter of 2018 compared to a net loss of $73.7 million for the comparable period of 2017.Cash Position: Cash, cash equivalents, and marketable securities as of September 30, 2018 were $1.0 billion, compared with $518.8 million at December 31, 2017. The increase was primarily due to net proceeds of $631.2 million from Sage's follow-on public offering completed in February 2018, and an upfront milestone payment from Shionogi & Co., Ltd. related to the strategic collaboration that was entered in June 2018.

Financial Guidance:

Based on its current operating plan, Sage anticipates that its existing cash, cash equivalents and marketable securities as of September 30, 2018 will enable Sage to fund its operating expenses and capital expenditure requirements into 2020.Sage expects that its operating expenses will increase year-over-year in 2018 to support continued pipeline advancement, including ongoing Phase 3 development of SAGE-217, and potential commercialization of ZULRESSO in PPD, if approved.

Conference Call InformationSage will host a conference call and webcast on Tuesday, November 6, 2018 at 8:00 AM ET to report its third quarter 2018 financial results and to discuss recent business updates. The live webcast can be accessed on the investor page of Sage's website at investor.sagerx.com. The conference call can be accessed by dialing (866) 450-8683 (toll-free domestic) or (281) 542-4847 (international) and using the conference ID 1891169. A replay of the webcast will be available on Sage's website approximately two hours after the completion of the event and will be archived for up to 30 days.

About Sage TherapeuticsSage Therapeutics is a clinical-stage biopharmaceutical company committed to developing novel medicines to transform the lives of patients with life-altering CNS disorders. Sage's lead product candidate, ZULRESSO™ (brexanolone) injection, has completed Phase 3 clinical development for postpartum depression and a New Drug Application is currently under review with the U.S. Food and Drug Administration. Sage is developing a portfolio of novel product candidates targeting critical CNS receptor systems, including SAGE-217, which is in Phase 3 development in major depressive disorder and postpartum depression. For more information, please visit www.sagerx.com.

Forward-Looking StatementsVarious statements in this release concern Sage's future expectations, plans and prospects, including without limitation: our expectations regarding the potential for approval of our NDA for ZULRESSO in the treatment of PPD, including the target timing of a decision by the FDA; our plans regarding the timing of launch of ZULRESSO in PPD and future commercial activities, if approved; our plans for determining the potential regulatory pathway for brexanolone injection in the EU; our statements regarding plans and timelines for development of SAGE-217 and our other product candidates, including planned clinical and regulatory activities;our views as to the opportunity represented by Sage’s portfolio and business; and our expectations regarding increases in operating expense, use of cash and future cash needs. These forward-looking statements are neither promises nor guarantees of future performance, and are subject to a variety of risks and uncertainties, many of which are beyond our control, which could cause actual results to differ materially from those contemplated in these forward-looking statements, including the risks that: the FDA may not agree with the recommendation of the Advisory Committees, and may decide not to approve our NDA for ZULRESSO in PPD; the clinical and non-clinical data we have generated with our proprietary formulation of brexanolone to date may be determined by the FDA, the EMA and other regulatory authorities to be insufficient to gain regulatory approval to launch and commercialize our product in PPD and regulatory authorities may determine that additional trials or data are necessary in order to file for or obtain approval; the FDA may not complete its review of our filing within the target timelines; even if ZULRESSO issuccessfully approved for PPD in the U.S., we may encounter issues, delays or other challenges in launching or commercializing the product, including issues related to market acceptance and reimbursement, challenges associated with restrictions or conditions that may be imposed by regulatory authorities, including challenges related to limiting the site of administration to a certified healthcare facility monitored by a qualified healthcare provider, and the necessity for a REMS; and challenges associated with the build of our sales and patient support organizations and their activities, which in each case could limit the potential of our product; we may encounter unexpected safety or tolerability issues with ZULRESSO, SAGE-217 or any of our other product candidates in ongoing or future development; we may not be successful in our development of SAGE-217 or any of our other product candidates in any indication we are currently pursuing or may in the future pursue; success in early stage clinical trials may not be repeated or observed in ongoing or future studies of SAGE-217 or any of our other product candidates; ongoing and future clinical results may not support further development or be sufficient to gain regulatory approval of our product candidates; we may decide that a development pathway for one of our product candidates in one or more indications is no longer feasible or advisable or that the unmet need no longer exists; decisions or actions of the FDA or other regulatory agencies may affect the initiation, timing, design, size, progress and cost of clinical trials and our ability to proceed with further development or may impact the regulatory pathway; we may experience slower than expected enrollment in ongoing clinical trials; the internal and external costs required for our activities, and to build our organization in connection with such activities, and the resulting use of cash, may be higher than expected, or we may conduct additional clinical trials or pre-clinical studies, or engage in new activities, requiring additional expenditures and using cash more quickly than anticipated; and we may encounter technical and other unexpected hurdles in the development, manufacture and potential future commercialization of our product candidates; as well as those risks more fully discussed in the section entitled "Risk Factors" in our most recent Quarterly Report on Form 10-Q, and discussions of potential risks, uncertainties, and other important factors in our subsequent filings with the Securities and Exchange Commission. In addition, any forward-looking statements represent our views only as of today, and should not be relied upon as representing our views as of any subsequent date. We explicitly disclaim any obligation to update any forward-looking statements.

View source version on businesswire.com:https://www.businesswire.com/news/home/20181106005268/en/

CONTACT: Sage Therapeutics, Inc.

Investor Contact:

Paul Cox, 617-299-8377

paul.cox@sagerx.com

or

Media Contact:

Maureen L. Suda, 585-355-1134

maureen.suda@sagerx.com

KEYWORD: UNITED STATES NORTH AMERICA MASSACHUSETTS

INDUSTRY KEYWORD: HEALTH BIOTECHNOLOGY CLINICAL TRIALS MENTAL HEALTH PHARMACEUTICAL FDA

SOURCE: Sage Therapeutics, Inc.

Copyright Business Wire 2018.

PUB: 11/06/2018 06:30 AM/DISC: 11/06/2018 06:30 AM

http://www.businesswire.com/news/home/20181106005268/en

Copyright Business Wire 2018.

© 2018 The Associated Press. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.


Community News For The Valley Edition | killexams.com real questions and Pass4sure dumps

CT Daylily Society Meeting

AVON — On Saturday, Nov. 3, the Connecticut Daylily Society will welcome Anna Carlson of Jordan, N.Y. Carlson is an avid gardener and daylily hybridizer who first began dabbling with daylily pollen 13 years ago. After only a season of hybridizing, she realized she needed more space than her small city plot offered. She embarked upon a search for the perfect location to put down daylily roots, and eventually came upon her current two-acre property. Complete with historic farmhouse, majestic trees, and plenty of sun, her new home was christened RavenCroft Cottage.

Carlson hybridizes both diploids and tetraploids, with a keen interest in unusual forms and red-hot colors. Of course, the occasional round and ruffled bloom can also be found in her collection of 35 registrations. Visit www.ravencroftcottage.com for more information.

A social hour and potluck lunch begins at noon, followed by a brief business meeting. Carlson's presentation will begin at 1 p.m. There will be daylily door prizes and attendance is free of charge. The Connecticut Daylily Society invites anyone with a passion for plants.

The Avon Senior Center is located at 635 West Avon Road, at the junction of Sycamore and Scoville Roads, at the Sycamore Hills Recreation Center. Visit https://ctdaylilyclub.com for more information on the Connecticut Daylily Society.

Drop-In Genealogy

SIMSBURY — Simsbury Free Library, 749 Hopmeadow St., is hosting drop-in genealogy. To RSVP or for more information, visit www.simsburyfreelibrary.org or call 860-408-1336.

Start cultivating your family tree with experienced Genealogist Alison Watson Maston at the drop-in genealogy event. The popularity of at-home DNA testing kits has made many people curious to learn more about their actual relatives. The Simsbury Free Library is a treasure trove of genealogical research. The library's experienced staff is eager and ready to help you dig deeper into your family history and document your family's roots to create a personalized holiday gift.

Drop-In Genealogy: Saturday, Nov. 10, from 10 a.m. to 2 p.m. Bring any information you have. Maston has over 40 years of experience and specializes in researching vital records, land records, immigration, naturalization and probate records. She has particular expertise in New England, New York City and Ireland. Free to members; $5 for non-members.

Civic Engagement Talk

FARMINGTON — Tunxis Community College's Civic Engagement Institute invites the community to the following free lectures and discussions during the semester in the 600 Building, Room 6-127, at 271 Scott Swamp Road. Light refreshments will be served.

During inclement weather, check the Tunxis website for updates at tunxis.edu, since events will be canceled or postponed if the college is closed. Email rfierro@tunxis.edu for more information.

Monday, Nov. 5, at 1 p.m. A panel of experts from Wheeler Clinic will discuss "Mental Health Strategies for Victims & Families of School Shootings."

Tuesday, Nov. 13, at 11:40 a.m. Join Tunxis professors Bob Brown and Dr. Rafaele Fierro, for a discussion on "Assessing the 2018 Mid-Term Elections: What Happened and How It Might Impact You."

Thursday, Dec. 6, at 1:15 p.m. A discussion on "Gun Violence and School Shootings, a Cultural Explanation," co-sponsored with Phi Theta Kappa.

Multicultural Arts & Technology Saturday Program

FARMINGTON — The Multicultural Arts & Technology Saturday Program at Tunxis Community College, 271 Scott Swamp Road, is now in its third year. It is open to all students grades two to six in the Hartford region who have an interest in arts & technology. Sponsored by Farmington Continuing Education in collaboration with Tunxis Community College, the program promotes learning through activities that include visual art, computer technology as a means of expression, African drumming, Chinese arts, dance and creative writing.

Taught by certified teachers and professional artists, the Saturday program will be held at Tunxis Community College on Nov. 3, 10, 17, Dec. 1, 8 and 15, from 8:30 a.m. to 12:30 p.m. Field trips include the Mark Twain Museum & New Britain Museum of American Art. A sharing of learning experiences with parents will be held Dec. 15 from 11:30 a.m. to 12:30 p.m. at Tunxis. Farmington Public School art teachers Nicole Bastiaans-Fritch and Andrew Minor lead a staff of professional artists and performers to offer hands-on learning experiences with a variety of art media.

Jane DePole-Bogucki, who has taught art at The Mattatuck Museum, specializes in art for young people. Professional performers include African drumming instructor Lance James, and dance instructor, Oswaldo Tirano, from Columbia, South America specializing in a variety of Caribbean and Latin dance forms for children including the use of puppetry in dance. Professional musician Hsiu-Chi Liange from Tiwain and her assistants provide instruction in Chinese string instruments and Chinese art. The tuition fee of $25 includes art supplies, a backpack and snacks courtesy of Tunxis Community College, and use of all multicultural musical instruments. Register online at www.fpsct.org/fce or by phone at 860-404-0290.

Connecticut Valley Tobacco: A Lecture & Book Signing

SIMSBURY — Historic Sites of Connecticut's Farmington Valley will present a lecture and book signing with Brianna Dunlap, a non-profit development professional with Connecticut Farmland Trust, Board Director of the Connecticut Valley Tobacco Historical Society in Windsor , and author of "Connecticut Valley Tobacco."

Dunlap will be at the Simsbury Historical Society's Ellsworth Center, 800 Hopmeadow St., on Sunday, Nov. 4, at 1 p.m., to present the story of the tobacco crop over nearly four centuries from southern Connecticut up to Brattleboro, Vermont. Admission is $5 per person.

Dunlap worked at the Connecticut Valley Tobacco Museum from 2013 until 2016. She graduated from Central Connecticut State University with a master's degree in public history in 2016. "Connecticut Valley Tobacco" is her master's project and a work meant for the public to enjoy. The book also features photography by Windsor native and well-known photographer Leonard Hellerman. Copies of the book will be available for purchase and signing at the lecture.

Proceeds from the lecture benefit Historic Sites of Connecticut's Farmington Valley, whose mission is to enhance appreciation of the Farmington Valley's rich history by promoting communication among heritage groups and offering unique programs. For more information, email Nancy.Anstey@comcast.net or call Nancy Anstey at 860-680-5298.

Community Scanning Days: Preserve Family Photos

FARMINGTON — The Farmington Libraries invites the public to digitally scan and save family memories by making an appointment with the resident scanning specialist. Appointments are available on Wednesday, Nov. 7, from 1 to 9 p.m. and Saturday, Nov. 10, from 9 a.m. to 5 p.m. at the Farmington Main Library, located at 6 Monteith Drive.

Call today to register for a one-on-one appointment to scan your photos, 35mm slides, negatives, postcards or letters. Library staff will scan and save as many as possible during the one-hour session. Have too much for just an hour? Sign up to get your project started and then schedule a training session to learn to use the equipment yourself. Then you will be able to come back and finish your project at your own pace.

Each participant will be assigned a one-hour time slot by the staff member running the program. Time slots will be reserved in the order that the reservations are received. An email will be sent to each registrant confirming their time slot. If you are unable to come at your appointed time, contact the program coordinator at your earliest convenience so they may open the spot to another individual. Registrants must be age 16 or older.

This event is free and open to the public. Call 860-673-6791 or visit the library's website, www.farmingtonlibraries.org, for details or to register for a time slot.

Mindful Movement Workshop

FARMINGTON — On Thursday, Nov. 8, the Farmington Libraries will host a free class on mindful movement. The program will begin at 6:30 p.m. at the Farmington Main Library, located at 6 Monteith Drive.

Angela Mazur and Theresa Nygren return to guide participants through an experiential hour of participating in Let Your Yoga Dance combined with some time for guided meditation. Let Your Yoga Dance is a joyful and energizing session that will awaken your spirit and move your body. All are welcome. No experience of any kind is required. Wear loose and comfortable clothing and bring a water bottle.

The class is presented by Angela Mazur, LCSW, LLC, and Theresa Nygren, LCSW. Visit www.mindfulselfcompassionateway.com for more information. This event is free and open to the public. Space is limited and registration is required. Visit www.farmingtonlibraries.org or call 860-673-6791 for details or to register.

Prosser Library Events

BLOOMFIELD — Prosser Public Library, 1 Tunxis Ave., is hosting the following events. Visit www.prosserlibrary.info or call 860-243-9721, ext. 3558, for more information. The events take place in the Prosser Public Library Community Room or the Adult Reading Room, unless otherwise noted.

"In Syria" International Film: Friday, Nov. 2, at 1:30 p.m. A film by Phillippe van Leeuw, from Belgium, France & Lebanon. 86 minutes. In Arabic with English subtitles. See the film and stay for casual conversation afterward. No registration necessary.

Free Diabetes Self-Management Workshop: Continues with sessions 5, 6 and 7 on Monday, Nov. 2, 5 and 16, at 10:30 a.m. This workshop is for individuals with type 2 diabetes whether you are newly diagnosed or simply need a refresher. Topics covered include: meal planning and holiday food choices, label reading, glucose monitoring and target blood glucose levels, medications, exercising safely and more. The sessions are interactive, so bring your questions. All participants receive a copy of the book, Taking Charge of Your Diabetes. Join Registered Dietitian and Certified Diabetes Educator, Paula Kellogg Leibovitz and register today online, or by calling the West Hartford- Bloomfield Health District, 860-561-7900, ext. 0. Pre-registration is required. This series is sponsored by the library and the West Hartford/Bloomfield Health District.

Chess: Monday, Nov. 5,19 and 26, at 4 p.m. Find someone new to play with or help the beginners strengthen their game. Basic instruction will be provided for beginners. All Ages.

"Maigret & the Fortuneteller" Mystery Book Discussion: Monday, Nov. 5, at 6:15 p.m. All readers are welcome to join one or all of the mystery book discussions at Prosser. Copies of the selected mystery title will be available at Prosser. Register to participate.

21st Century Composers, Music Appreciation: Tuesday, Nov. 6, at 1 p.m. Russ Salk will bring his collection of recordings by contemporary composers. Enjoy musical excerpts and learn a bit about selected contemporary composers. Registration is appreciated.

"Marnie" Opera Talk, J. Engel: Wednesday, Nov. 7, at 1 p.m. Composer Nico Muhly unveils his second new opera for the Met with this gripping reimagining of Winston Graham's novel, set in the 1950s, about a beautiful, mysterious young woman who assumes multiple identities. Music historian Jeffrey Engel will present the opera talk, offering historical context for the composer and the opera story. Registration is appreciated.

Caregiver Support Group/Healing Hearts: Wednesday, Nov. 7, at 1:30 p.m. Location: Marilyn Michaelson Senior Center, 330 Park Ave., Bloomfield. Are you sometimes overwhelmed by your responsibilities as a caregiver?.Do you have questions but are not sure who to ask? Do you have a loved one in hospice? Are you grieving after a loss? Feeling alone? Don't know where to turn? Please consider coming to Bloomfield's Caregiver & Healing Hearts support groups. Facilitators: Lucille Morisse, Social Worker, & Mara Whitman, Adult Services Librarian. For more information, call the Senior Center at 860-243-8361.

Edible Perennial Gardening and Landscaping: Wednesday, Nov. 7, at 3 p.m. A PowerPoint presentation by John Root, featuring the variety of trees, shrubs, vines, canes, and herbaceous perennials that can be grown in New England for bountiful harvests of fruits, nuts and vegetables. Participants will learn how to establish and care for these plants using organic methods of cultivation. Nutritional and medicinal benefits of the plants will be discussed as well. Questions and comments are welcome throughout the presentation, and handouts with a list of edible perennial plant species, resources for further study, and recommended plant nurseries will be distributed at the conclusion of the program. Root is a naturalist and educator based in Massachusetts. Registration is appreciated. Co-sponsored with the Dun-Land-Woods Garden Club.

Footprints Across Connecticut, a Wintonbury Historical Society Program: Wednesday, Nov. 7, at 6:30 p.m. In her new publication, "Footprints Across Connecticut From The 1930 Bloomfield Census," local genealogist Jean Perreault has documented the life histories of all 3,248 Bloomfield residents who were living here at that time. Most of these individuals are now deceased but they left behind a trail of interesting facts regarding their lives, including their origins, their occupations and their progeny. For anyone wondering about a long lost relative or friend this research book could prove to be a valuable source of information. The author will explain how to access the many genealogical sources which are made available to us all in today's digital age. The Bloomfield book is the third in her Footprints series. The towns of East Granby, Granby and Simsbury are documented in the author's other two books. Copies of her books will be available for purchase at $20 per volume. The program is cosponsored by the library and the Wintonbury Historical Society. Registration is appreciated.

Microsoft PowerPoint Level 2: Thursday, Nov. 8, at 11 a.m. Participants will learn how to add transitions and animations to a slideshow presentation in Microsoft PowerPoint 2016. Prerequisite: Familiarity with a computer, keyboard, and mouse. Each participant will use a library laptop. Register, as class space is limited.

Chill Out & Knit: Thursdays, Nov. 8 and 29, at 3:45 p.m. New members of all ages and experience are welcome to drop in and join this group of knitters in the Community Room. Knitters will guide one another with creative new projects or tinkering with an old one. No registration required.

Book Discussion, "The Wonder" by Emma Donoghue: Thursday, Nov. 15, at 6:30 p.m. Please note the date change. Location: McMahon Wintonbury Library Adult Reading Room. All readers are welcome. Copies of the book are available at the library. Registration is appreciated.

Pedro & Naomi Centeno, Artists Reception: Friday, Nov. 9, at 4 p.m. Refreshments will be served. No registration necessary.

"This Business of Fighting," Arnie Pritchard Storyteller/Historian, a Spotlight Sunday Program: Sunday, Nov. 11, at 2 p.m. Pritchard puts a human face on World War II with stories based on his father's time in the front lines in Europe. His presentation portrays a young man dealing with everything from raw fear to his role as a leader to his exposure to a world both wider and more brutal than he had known. Registration is appreciated. The Spotlight Sunday series is sponsored by the Friends of the Bloomfield Public Libraries.

"Delacroix" Art Film & Conversation With Jack Brin: Tuesday, Nov. 13, at 1 p.m. This season's films are from a collection of artist biographies entitled "Romantics and Realists." The meetings will take place on Tuesdays at 1 p.m. The DVDs are each 50 minutes long. Join Brin for insight into the lives of Francisco Goya, Caspar David Friedrich, Eugene Delacroix and Dante Gabriel Rossetti. Registration is appreciated.

Library Board Meeting: Tuesday, Nov. 13, at 5 p.m. Location: Prosser Public Library Community Room.

Rossini: Wednesday, Nov. 14, 1 p.m. Gioachino Rossini was the supreme composer of Italian opera during the first half of the nineteenth century. He was also extremely prolific. During a span of 10 years, he produced 30 operas, and most of them were successful. As the age of 37, though Rossini lived nearly 40 more years, he put down his pen and never wrote another opera again. This program will follow the odd arc of Rossini's career and will explore his less familiar instrumental and vocal works. Join music historian Jeffrey Engel for today's music history and appreciation talk. Registration is appreciated.

Mindfulness Meditation for Adults: Wednesday, Nov. 14, at 6:30 p.m. Learn techniques of visualization, affirmation, and body awareness to enjoy a sense of abundance and peace in your life. Devin McCrorey has studied meditation as a means to overcome depression, anxiety and trauma. For the last five years, he has been teaching meditation to children, teens and adults. Please register.

Wintonbury Poetry Series: Thursday, Nov. 15, at 7 p.m. Where: McMahon Wintonbury Library Children's Room. Two Women Poets of Diverse Talents: Eileen Albrizio and Leslie McGrath. Wethersfield poet Albrizio, former ABC and NPR radio news host and journalist and co-owner of a comic book store in Rocky Hill, writes novels, short stories, plays and poetry and will read from her poetry collections. Essex poet McGrath has been called an oral historian of the alienated. A creative writing teacher at Central CT State University, she has published three poetry collections and two chapbooks and has won the Pablo Neruda Prize for Poetry.

South African Book Discussion

AVON — The Avon Free Public Library International Book Discussion Series, featuring South Africa, will take place at 281 Country Club Road.

The schedule is as follows: Monday, Nov. 5, at 2 p.m., "The Fever Tree" by Jennifer McVeigh; Monday, Dec. 3, at 2 p.m., "Philida: a Novel" by Andre Brink; and Monday, Jan. 7, 2019, at 2 p.m., "Hum If You Don't Know the Words" by Bianca Marais.

This is a book discussion featuring fictional books set in South Africa and is led by Cyndi Larsen. Call 860-673-9712 or email clarsen@avonctlibrary.info for more information. The discussions are free and open to the public. No registration is required.

First Friday Dinners

AVON — The next First Friday Dinner at Avon Congregational Church, 6 W. Main St., will take place on Nov. 2 from 5:30 to 7 p.m.

The menu will feature chicken parisienne, vegetables, breads and a dessert buffet, including coffee and tea. Call the church office at 860-678-0488 for more information. The dinners are $13 per adult and $7 per child 10 and under. A portion of the dinner proceeds will go to Hands on Hartford, a social service nonprofit organization that serves 10,000 of Hartford's neediest residents annually. Dine-in or take-out is available.

Harvest Breakfast

AVON — The Avon Lions Club will host its annual Harvest Breakfast fundraiser on Sunday, Nov. 4, from 8 to 11 a.m. at the 1st Company, Governor's Horse Guard facility, 280 Arch Road.

The menu will feature scrambled eggs, bacon, sausage, hash brown potatoes, muffins, juice, coffee and tea. Ticket prices are $10 for adults and $5 for children five to 12. Children four and under may attend for free.

Tickets can be purchased at the door or from any member of the Avon Lions Club. There will be a raffle with gift certificates to local restaurants, merchants and gift baskets. The public is invited to bring their used eyeglasses, hearing aids, and cell phones for recycling.

The funds raised at this event are used by the Avon Lions Charities, Inc. to support charities, civic outreach organizations, and eyesight-related services at the local, regional, and international levels. These include Avon Dollars for Scholars, Avon Social Services, the American School for the Deaf, Gifts of Love, The Juvenile Diabetes Research Foundation, the Lions Low Vision Center, and others.

Contact the Avon Lions Membership Chair Gene Bourquin at 860-989-5010 or visit http://e-clubhouse.org/sites/avonct for more information.

A Toast To Women

AVON — Soroptimist International of the Americas Northeastern Region's A Toast to Women, An Evening Celebrating Soroptimist and its Dream Programs, will take place from 6 to 11 p.m. Friday, Nov. 2, at Avon Old Farms Hotel, 279 Avon Mountain Road.

Cost to attend is $65 for a single ticket and $120 per pair, advanced sales only. Visit www.atoasttowomen.org or contact Joan at 860-428-1230 for more information.

The evening will feature food, dancing, holiday shopping and more. Scheduled to inspire attendees is Dr. Dorothy Martin-Neville and music for dancing will be provided by Rick Hall Entertainment. Proceeds from this event will support Soroptimist "Live Your Dream" awards and "Dream It Be It" career support programs that improve the lives of women and girls.

This event is limited to 110 attendees. If not sold out, a limited number of tickets for $75 each will be available the day of the event.

Clothing Sale

AVON — A sale of gently used clothing will be held on Nov. 2 and 3 in the Father Bennett Hall at St. Ann's Church, at the corner of West Avon Road and Arch Road. Hours are Friday from 6 to 8 p.m. at a $5 per adult admission, and Saturday from 8:30 to 11 a.m., followed by a bag sale from noon until 2 p.m. There is no admission fee on Saturday.

Payment may be made by cash or check. Quality, pre-loved clothing will be available for men, women, teens, children, and infants at great prices. There will be a jewelry, boutique and shoe section. The sale benefits St. Ann's Social Justice Scholarship Program, which sponsors deserving urban students from all backgrounds and faiths by providing partial tuition support to attend area Catholic high schools. For further information, call Meg Kundahl at 860-521-1051.

An Evening Of Jazz

AVON — The Dan Liparini Trio will be performing an evening of jazz music at West Avon Congregational Church, 280 Country Club Road, on Friday, Nov. 2, at 7:30 p.m. The trio plays original instrumental music that has its roots in jazz, but also draws from folk and electronic music. Joining Liparini are Matt Dwonsyzk and Kirk Woodward, all graduates of the Hartt School of Music. Cost to attend is $10 per person. For further information, contact West Avon Congregational Church at wacc@snet.net or 860-673-3996.

Gifts Of Love Benefit Gala

HARTFORD — Gifts of Love will host its annual gala benefit on Saturday, Nov. 3, from 6 to 11 p.m. at Infinity Music Hall, 32 Front St. Over the past 29 years, Gifts of Love programs in Avon and Simsbury have served thousands of individuals and families in 30 towns in Greater Hartford who have been impacted by financial crisis through providing HOPE with services and education.

The event will include a cocktail hour with open bar, silent and live action, sit-down dinner, music by The Bookman Styles Band with Latanya Farrell, dancing and a look at Gift's of Love's impact on the community. Corey Meyers of Country 92.5 Radio will serve as the evening's emcee and i-heart media's Renee DiNino will be this year's auctioneer.

The event will be honoring Stanley Black and Decker, who has been a strong supporter of Gifts of Love for many years. This year's Diamond Sponsor is Stanley Black & Decker, Gold Sponsor is The Shoppes at Farmington Valley, The Barnes Group and the Hair Loft. Our Silver Sponsors include Brescia's Printing Services, Inc., ENE Realty, Farmington Bank, Palmer Latko Ledas Page, Hoffman Auto Group, Nathan Accounting Group, and The Hartford. Additional sponsors are Carmon Community Funeral Homes, Norcom Mortgage and Insurance, The Travelers Companies, Ensign Bickford Aerospace & Defense and Simsbury Bank.

Help commemorate this annual benefit by wearing favorite cocktail attire or roaring 20's attire. Tickets are $150 per person. A table of 10 costs $1,250. Visit www.giftsoflovect.org for more information.

Aura Hall Craft Fair

VOLUNTOWN — Aura Hall's annual craft and vendor fair will take place from 9 a.m. to 1 p.m. Saturday, Nov. 3, at 51 Lillibridge Ave. Handmade items, pet items, goat milk soap, candles, jewelry, a bake sale, lunch and more are part of the festivities. Call 860-376-2696 for more information.

Popular Songs Of 1818

AVON — The People Have Sung: Popular Songs of 1818 will take place at 2 p.m. Wednesday, Nov. 7, at the Avon Senior Center, 635 West Avon Road.

Funded by a grant from CT Humanities, this program includes songs that were popular or familiar in Connecticut during the period. The discussion will include background on the songs and how they reflected the cultural, political or just plain human sensibilities of the day.

Songs that were already well-known in the Colonial era were still widely popular in 1818. More modern songs from the time of the 1812 war were entering the public domain. An interesting mix of sounds was evolving during this part of history and popular songs, new and old, were being sung in parlors, taverns and concert gatherings across Connecticut. The talk will be presented by music historians Rick Spencer and Dawn Indermuehle. Free, no registration required.

Blood Pressure Screenings

AVON — Free blood pressure screening dates at the Avon Public Library, 281 Country Club Road, will take place from 12:15 to 1:45 p.m. on the following Thursdays: Nov. 15, Dec. 6 and Dec. 20.

A community service of the Farmington Valley Visiting Nurses Association, the screenings are free and all are welcome. Registration is not necessary, just drop-in. For more information, contact Patrice Celli at 860-673-9712, ext. 234.

Italian-American Culture: From Ellis Island To Today

FARMINGTON — The Farmington Libraries will host an event celebrating Italian Americans, presented by Dr. Carl Antonucci and Professor Kenneth DiMaggio of Central Connecticut State University, at the Farmington Main Library, 6 Monteith Drive.

The talk will celebrate the history, sights, sounds, and flavors of this vital segment of the population and will include a light Italian dinner. The schedule is as follows:

Discover Italian-American food, film and music from the Italian-American neighborhoods of the 1940s and 1950s to the Italian American neighborhoods of today, on Tuesday, Nov. 27, at 6 p.m. The event is free and open to the public. Please register. Visit www.farmingtonlibraries.org or call 860-673-6791 for details or to register.

Collecting Socks For The Homeless

AREA — During October, the children, families and friends of the Greater Hartford Chapter of Jack and Jill will collect new socks to benefit their neighbors experiencing homelessness. Socks are the least donated item to shelters and the most needed; as temperatures are dropping and bad footcare can worsen medical complications.

This service project will come full circle in early November, as the organization will partner with Church Army, USA, a local non profit in Hartford, to personally hand out the donated socks to those in need and also provide them with food.

New socks can be dropped off in bins located in the lobby of Amped Fitness, 55 Mill St., Unionville, and the lobby of Olympic Taekwondo Academy, 45 S. Main St., Unionville.

Gallery on the Green

CANTON — Canton's Gallery on the Green presents its 51st annual open juried exhibition and solo exhibition by Susan Bradley. The show runs through Saturday, Nov. 10. Gallery hours are Friday through Sunday from 1 to 5 p.m. The gallery is located near the intersection of Dowd Avenue and Route 44 at 5 Canton Green Road. The main floor gallery is handicapped accessible.

The selections were made by Melanie Carr, owner of Melanie Carr Gallery in Essex. As this is an open exhibition, it features the work of artists from all over Connecticut and beyond.

Susan Bradley has a solo show of her oil paintings. The show is entitled "Crossroads" and reflects her love of drawing the human form. Visit www.galleryonthegreen.org, email CantonArtists@att.net or call 860-693-4102 for more information.

Film Series Continues

AVON — The Avon Public Library, 281 Country Club Road, continues its outstanding film series. For more information, visit www.avonctlibrary.info or call 860-673-9712.

The film introduction and post film discussion will be led by local film expert Bob Kagan. Guests may bring snacks to share. The film screening is free and open to the public. Registration is not required.

The schedule continues: Thursday, Nov. 15, at 6:30 p.m. Film: Water, 2006, Rated PG-13. This film will be shown with subtitles; and Thursday, Dec. 13, at 6:30 p.m. Film: My Left Foot, 1989, Rated R. This film will be shown with subtitles.


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State of counter-drone regulation for public safety and physical security

In 1901 New York state made a pioneering regulation move and became the first US state to require automobile owners to register their vehicles. This marked the beginning of regulation on modern traffic, which - following decades of development - resulted in a multi-layer concept of regulation relating to vehicles and driver’s licenses, traffic signs and insurance mechanisms that we are all familiar with nowadays. While certain parallels can be drawn between the early days of cars and our contemporary experience with quadcopters, we are facing a new challenging era that is far more complex to organise and regulate. Integrating drones in existing regulatory ecosystem Similar to other pioneering technologies in the past, drones need to integrate into a long existing and well-balanced ecosystem, the rules of which have first been drafted some one hundred years ago and have evolved without taking vehicles such as drones into account. Yet the safety risks related to aviation hinder the quick integration of drones into that ecosystem, broadening the gap between existing regulatory landscape and the exponentially growing popularity and ever-advancing technology of drones. The safety risks related to aviation hinder the quick integration of drones into the legislative ecosystem For the past several years, governments and legislators have been trying to tackle this problem by trying to answer two questions: how to properly integrate drones into the airspace without creating a hazardous impact on existing airborne operations, and how to enforce regulations in order to prevent the side-effects related to careless or malicious drone flights, taking into consideration public safety and physical security. Counter-UAS measures and regulations Up until 2018, legislators tried to tackle these two questions as a whole by introducing bundled legislation drafts covering the entire landscape of gaps they needed to address, which resulted in multi-parliamentary committee efforts both in the US and abroad to review and approve each bill - a process that is very slow by design. It was only in the beginning of this year that the issues were starting to be addressed separately: legislation related to limitations and counter-drone measures on the one hand, and legislation related to integration into airspace on the other. Let’s take a closer look at Counter-UAS (unmanned aerial systems) measures and what makes them challenging in terms of regulation. Over the past years, various counter-drone technologies have been introduced to enable control over rogue drones in order to either stop them from achieving their flight purpose or prevent them from creating safety hazards to people or property. These measures can be grouped into 3 types of technologies: Military grade solutions - including lasers and surface-air missiles Kinetic solutions - including net-guns and autonomous drones set out to catch the rogue drone and disable it airborne Non-kinetic RF-based solutions - aimed at either disabling, disrupting or accessing the drone’s communications channels in order to trigger a return-to-home function, or guide the drone into a safe landing route Aside from combat military operations, the legality of using the above technologies is questionable as they tamper with an airborne aircraft, might be considered as wiretapping and/or violate computer fraud laws. Therefore, one can conclude that unless changes to regulation are made, non-military facilities will continue to be defenceless from and vulnerable to rogue drones.  One can conclude that unless changes to regulation are made, non-military facilities will continue to be defenceless from and vulnerable to rogue drones European c-UAS legislation Next, let’s look at the state of c-UAS legislation in both Europe and US to better understand different legislative ecosystems and how they affect the possibilities of using counter drone measures. In the European Union, there is currently no uniform legislation, and the member countries rely on their own existing legal infrastructures. Roughly speaking, most countries use a method of exemptions to the communications and aviation laws to allow the use of counter drone measures after a close examination by the relevant authorities. Such exemptions are approved under scrutiny to particular sites, which provide some relief, but they do not allow broad use of countermeasures. Further discussion regarding a broader regulation change, on a country level or EU-wide, is only preliminary. US c-UAS legislation Preventing Emerging Threats - provides an initial infrastructure for counter drone measures to be used by various DoJ and DHS agenciesUnlike the EU, in the US exemptions are not possible within the existing legal framework, and the possible violation of US code title 18 means that the hands of both the government or private entities are tied when attempting to protect mass public gatherings, sports venues, or critical infrastructure. Therefore, it was more urgent to introduce legislation that would allow countermeasures to some extent. In September, US Congress approved the FAA-reauthorisation act for the next 5 years (H.R. 302), which was shortly after signed by the President and came into effect. Division H of the act - Preventing Emerging Threats - provides an initial infrastructure for counter drone measures to be used by various DoJ (Department of Justice) and DHS (Department of Homeland Security) agencies under strict limitations. However, the act avoids determining which technology the agencies should use, yet it requires minimal impact on privacy and overall safety in order to strike the necessary balance. This is the first profound counter-drone legislation and is expected to be followed by additional measures both in the US and in other countries. Updating counter-drone legal infrastructure In summary, 2018 has been a pioneering year for counter-drone legislation, and while technology already allows taking action when necessary, legal infrastructure needs further updates in order to close the existing gaps: covering additional federal assets, state-level governments, and private facilities of high importance, such as critical infrastructure sites. Legislators in the US and around the world need to continue working in a rapid tempo to keep up with the growing threat of drones. As with cars a century ago, the number of accidents will rise with the increase in time taken to regulate.



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