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300-100 - LPIC-3 Exam 300: Mixed Environments, version 1.0 - BrainDump Information

Vendor Name : LPI
Exam Code : 300-100
Exam Name : LPIC-3 Exam 300: Mixed Environments, version 1.0
Questions and Answers : 118 Q & A
Updated On : January 17, 2019
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300-100 exam Dumps Source : LPIC-3 Exam 300: Mixed Environments, version 1.0

Test Code : 300-100
Test Name : LPIC-3 Exam 300: Mixed Environments, version 1.0
Vendor Name : LPI
Q&A : 118 Real Questions

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LPI LPIC-3 Exam 300: Mixed

LPI Certification tests Exceed 250,000 worldwide | killexams.com Real Questions and Pass4sure dumps

(Sacramento, CA, united states: June 24, 2010) The Linux professional Institute (LPI), the realm’s premier Linux certification corporation (http://www.lpi.org), announced that they delivered over 258,000 assessments and eighty five,000 certifications worldwide.

“this is a crucial milestone for the Linux professional Institute. It signifies the long-standing dedication to the LPI program from each individual Linux professionals and the trade at huge. we have considered incredible increase within the remaining yr as a result of the enthusiastic response from IT gurus to our revised LPIC-1 and LPIC-2 tests,” stated Jim Lacey, president and CEO of the Linux professional Institute. Mr. Lacey credited the dazzling results to a number of factors including the desire of IT specialists to retain their potential latest in a particularly aggressive economic climate: “IT specialists know that lifestyles-lengthy studying and established skills play a vital role in their profession routine. We also understand that attractive with the global Linux group is at the coronary heart of LPI’s success. The efforts of all who support the firm on an everyday groundwork made this milestone a truth. lastly, this demonstrates the price of seller-impartial certification usual, and showcases the superb efforts made by using our network of world affiliates to promote Linux professionalism.”

trade representatives were short to present notes of congratulations recognizing LPI’s contribution to the development of Linux schooling and professionalism:

CompTIA:

“The know-how adoption curve continues to accelerate, inserting expanding significance on the need to always replace the talents of the high-tech team of workers,” observed Terry Erdle, senior vice president, competencies certification, CompTIA, the non-income exchange affiliation for the IT trade.  “On-going schooling, practising and certification of expertise laborers isn’t a luxury, it’s a necessity,” Erdle continued. “LPI fills a vital position in the expert construction of existing and future IT worker; and this milestone is testament to the value that employers and individual employees place on their certification. CompTIA is joyful to associate with LPI as we work collectively to boost a robust Linux team of workers.”

IBM:

“IBM acknowledges LPI as a key aid to aid IT professionals profit Linux advantage,” mentioned Jean Staten Healy, Director of Linux method at IBM. “Linux continues to grow as a core technology for many of our purchasers, and that they require a talented technical group to assist them meet their enterprise desires.”

Linux groundwork:

“LPI has achieved another brilliant milestone,” talked about Amanda McPherson, vice chairman of advertising and marketing and developer features on the Linux foundation. “This success is a testomony to two issues: 1. LPI’s boom and sturdiness as a Linux certification leader and 2. the turning out to be number of Linux specialists. We see giant job boom for Linux experts even in this down market and LPI certification is a superb piece of that story.”

Linux foreign:

“As President of Linux international, I work with loads of emerging economies to advance new groups in the IT sector comparable to these based mostly on project Cauã in Brazil.  The undeniable fact that LPI publishes their test pursuits, sample tests and separates the idea of “training” from “certification” allows people in these economies to acquire certification on the lowest feasible cost.  I applaud LPI for achieving this milestone,” pointed out Jon “maddog” corridor, President, Linux overseas

Novell:

Congratulations to LPI on attaining this large milestone.  This success demonstrates the value of Linux certification to IT authorities.  In specific, for Linux certified IT specialists, the job outlook will proceed to brighten over the yr, in particular for these with the best abilities sets. Linux experts that obtain certification may have the technical skill and self assurance to handle nowadays’s distinct statistics core necessities, notably as cloud computing turns into greater mainstream,” noted Markus Rex, Senior vice chairman and everyday supervisor, Open Platform options, Novell

Pearson VUE:

“LPI continues to play a a must-have function in offering talents validation for IT employees as Linux continues to gain international popularity” pointed out Randy Trask, senior vice president of market construction at Pearson VUE. Randy persisted, “LPI’s fresh success is a mirrored image of the challenging work performed in forging alliances with the a large number of members of the Linux ecosystem and naturally demonstrates the demand for qualified Linux employees.”

Prometric:

“we might want to offer our straightforward congratulations to the Linux expert Institute for attaining such an brilliant milestone,” said invoice Murtagh, Prometric Senior vice chairman, earnings and client features. “we're satisfied to help the beginning of LPI assessments and their persevered increase in any manner we can.”

LPI offers a standardized, multi-countrywide and extremely revered program to certify ranges of expert potential in Linux. assessments are created the use of industry diagnosed psychometrics and skilled look at various development processes to be certain high exceptional exams with direct relevance these days’s in-demand competencies. LPI’s certification application is delivered worldwide in numerous languages with the aid of employers, companies and trainers. stage One and degree Two certifications (LPIC-1 and LPIC-2) mirror the a success completion of two assessments at every level. LPIC-three certification, launched in February 2007, requires completion of a single exam–however extra specialties in “combined ambiance” (LPI-302) and “security” (LPI-303) are additionally purchasable.

The Linux knowledgeable Institute (LPI) is globally supported by way of the IT business, enterprise and professionals and inside executive and the tutorial neighborhood. LPI’s certification application is delivered global in diverse languages at over 7,000 trying out areas and is supported via an affiliate community spanning 5 continents.

concerning the Linux skilled Institute:

The Linux skilled Institute promotes and certifies fundamental skills on Linux and Open source technologies throughout the global start of complete, most suitable, supplier-unbiased checks. based as an foreign non-earnings company in 1999 via the Linux group, the Linux professional Institute continues to show identified global leadership within the certification of Linux specialists. LPI advances the Linux and Open source movement through strategic partners, sponsorships, imaginitive programs and neighborhood construction activities. LPI’s major economic sponsors are Platinum Sponsors IBM, Linux Journal, Linux magazine, Novell, SGI, and TurboLinux as well as Gold Sponsors, HP and IDG. 


Linux skilled Institute to trade Linux Certification courses | killexams.com Real Questions and Pass4sure dumps

Feb 28, 2013

The Linux professional Institute (LPI), a Linux certification organization, is making changes to its LPIC-2 and LPIC-three certification programs. the new targets for these certifications are at the moment under building. New tests can be obtainable in English on October 1, 2013 with native translations and pricing to be introduced.

The Linux skilled Institute is globally supported by using the IT business, business customers, group professionals, government entities and the tutorial group. LPI's foremost monetary sponsors are platinum sponsors IBM, Linux Journal, Linux journal, Novell, SGI, and TurboLinux as well as gold sponsors, HP and IDG.

in keeping with the LPI, it's focusing on standard and superior gadget administration expertise in LPIC-2, whereas additional focusing the LPIC-three software on certain specialties such as combined environments, safety, and high availability/virtualization. The upcoming alterations additionally mirror LPI's work with the higher open source community in to verify the ability sets imperative for numerous really expert job roles for Linux professionals.

A revised program roadmap and an outline of proposed alterations to the LPIC-2 and LPIC-3 certification program will also be found here.


desirable 5 | Linux Certifications in 2018 | killexams.com Real Questions and Pass4sure dumps

1. LPIC (Linux skilled Institute Certification)

started back in 1999 with the aid of Linus Torvalds, these Linux certifications today has become vital for any Linux expert. This software is attainable in 4 distinct degrees, which might be:

LPI : Linux essentials Certification

The Linux essentials professional development certificates (PDC) also serves as an amazing stepping-stone to the more advanced LPIC skilled Certification song for Linux programs directors.

existing edition: 1.5 (examination code 010–150)

necessities: There are no prerequisites for this certification

necessities: Passing the Linux essentials 010 examination

Validity length: Lifetime

Languages: English, German. The exam may be written in the following languages best at paper-based exam pursuits: Portuguese (Brazilian), Italian, Spanish (contemporary), chinese language (Simplified), chinese language (average)

To receive the Linux necessities certificate the candidate should:

  • have an figuring out of the Linux and open supply business and abilities of the most established open supply purposes;
  • be mindful the essential accessories of the Linux working device, and have the technical proficiency to work on the Linux command line; and
  • have a fundamental understanding of protection and administration linked issues akin to person/group administration, engaged on the command line, and permissions.
  • LPIC- 1: Linux Administrator Certification

    LPIC-1 is the first certification in LPI’s multi-degree Linux skilled certification program. The LPIC-1 will validate the candidate’s capacity to perform protection tasks on the command line, deploy and configure a laptop working Linux and configure basic networking.

    The LPIC-1 is designed to replicate current analysis and validate a candidate’s proficiency in precise world system administration. The ambitions are tied to actual-world job potential, which we check through job task analysis surveying throughout examination construction.

    present edition: 4.0 (exam codes a hundred and one–400 and 102–400)

    necessities: There are not any prerequisites for this certification

    necessities: Passing tests 101 and 102

    Validity period: 5 years

    Languages: English, German, Italian, Portuguese (Brazilian), Spanish (up to date), chinese (Simplified), chinese language (typical) and japanese

    To turn into LPIC-1 licensed the candidate ought to be in a position to:

  • keep in mind the architecture of a Linux gadget;
  • install and keep a Linux pc, together with X11 and setup it up as a network customer;
  • work on the Linux command line, together with general GNU and Unix commands;
  • address data and access permissions as well as equipment security; and
  • perform convenient maintenance tasks: help users, add clients to a bigger device, backup and restoration, shutdown and reboot.
  • LPIC- 2: Linux Engineer Certification

    here's an superior stage Linux Certification, which requires an lively LPIC-1 certification. It has two assessments- First covers the file gadget and devices, kernel, equipment startup, network configuration, system renovation, storage administration, and even means planning and the second exam covers electronic mail capabilities, network client administration, area name servers, gadget security and troubleshooting.

    LPIC-2 is the 2d certification in LPI’s multi-degree professional certification software. The LPIC-2 will validate the candidate’s capacity to manage small to medium–sized mixed networks. The candidate must have an lively LPIC-1 certification to receive LPIC-2 certification, however the LPIC-1 and LPIC-2 tests may be taken in any order.

    current edition: 4.5 (exam codes 201–450 and 202–450).

    prerequisites: The candidate have to have an energetic LPIC-1 certification to acquire LPIC-2 certification, however the LPIC-1 and LPIC-2 tests could be taken in any order

    necessities: Passing assessments 201 and 202

    Validity duration: 5 years

    Languages: English, German, jap

    To turn into LPIC-2 licensed the candidate must be able to:

  • operate superior system administration, including regular initiatives concerning the Linux kernel, system startup and upkeep;
  • operate superior administration of block storage and file methods in addition to advanced networking and authentication and equipment protection, together with firewall and VPN;
  • installation and configure simple network features, including DHCP, DNS, SSH, internet servers, file servers the use of FTP, NFS and Samba, e-mail start; and
  • supervise assistants and recommend management on automation and purchases.
  • LPIC- three: Linux enterprise knowledgeable Certification

    it is a senior-level Linux certification, which wants an active LPIC-2 anyway passing any single examination within the 300 series. This certification includes exam IDs, which are:

  • 300: combined environment
  • 303: protection
  • 304: Virtualization and excessive Availability
  • 300: combined atmosphere covers Samba, work with Linux & home windows customer, and even plus OpenLDAP.

    303: safety covers operations, utility protection, and the community are lined below the protection exam besides cryptography and entry controls.

    304: Virtualization and high Availability covers virtualization and high availability cluster storage and engagement.

    current version: 1.0 (exam code 300–a hundred)

    must haves: The candidate have to have an active LPIC-2 certification to get hold of LPIC-three certification, however the LPIC-2 and LPIC-3 assessments can be taken in any order

    necessities: Passing the 300 examination

    Validity length: 5 years

    Languages: English, japanese

    2. CompTIA Linux+

    CompTIA Linux+ covers general initiatives in fundamental distributions of Linux, including the Linux command line, primary protection, setting up and configuring workstations, and networking.

    Let’s comprehend greater about these two Linux certifications here:

  • CompTIA Linux Certification (LX0–103) — defined
  • This look at various covers these few domains, which can be:

  • GNU and UNIX commands
  • gadget structure
  • Linux installing and package administration
  • gadgets, Linux Filesystems, Filesystem Hierarchy usual
  • 2. CompTIA Linux Certification (LX0–104) — defined

    This check covers these few domains, which can be:

  • protection
  • Shells, Scripting, and statistics management
  • consumer Interfaces and desktops
  • Administrative projects
  • basic device services
  • Networking Fundamentals
  • exam particulars

    examination Description: Linux+ is comprised of two checks — LX0–103 and LX0–104. Candidates must circulate LX0–103 before taking LX0–104. each verify Have:-

    number of Questions: 60 questions

    type of Questions: dissimilar choice (Single Response), varied Response and Fill-in-the-clean

    length of check: ninety Minutes

    Passing rating: 500 (on a scale of 200 to 800)

    counseled event: CompTIA A+, CompTIA community+ and 12 months of Linux admin experience

    Languages: English, German, Portuguese, Spanish

    rate: $206 USD (See all pricing)

    3. RHCE (pink Hat certified Engineer)

    The purple Hat licensed Engineer (RHCE) is a certification which you can earn to become a crimson Hat licensed device Administrator (RHCSA). The RHCE certification indicates that you've confirmed the abilities, skill and capacity required of senior gadget administrator answerable for red Hat commercial enterprise Linux programs.

    In case, you have earned RHCE, you turn into eligible for RHCA (crimson Hat licensed Architect) credentials together with:

  • RHCA: utility development
  • RHCA: Datacenter
  • RHCA: Cloud
  • RHCA: DevOps
  • RHCA: utility platform
  • 4. Oracle Linux

    Certifications comprise of two tests, which can be:

  • OCA- 1Z0–100 Oracle Linux 5 and 6 device Administration, needs 61% to move, and 80 questions to effort
  • OCP- 1Z0–105 Oracle Linux 6 advanced device Administrator, requires 61% to move, and has a total of ninety seven questions.
  • 5. GIAC certified UNIX safety Administrator (GCUX) Description

    GIAC licensed UNIX equipment administrators (GCUXs) have the capabilities, talents and talents to cozy and audit UNIX and Linux programs.

    target

    individuals answerable for installation, configuring, and monitoring UNIX and/or Linux techniques.

    *No specific practising is required for any GIAC certification. there are lots of sources of suggestions available involving the certification pursuits’ talents areas. practical event is an alternative; there are also a lot of books in the marketplace masking computer suggestions security. one more choice is any valuable lessons from training suppliers, including SANS.*

    necessities
  • 1 proctored exam
  • 75 questions
  • time limit of 2 hours
  • minimum Passing ranking of 68%
  • Renew

    Certifications have to be renewed every four years. click on here for details.

    start

    be aware: All GIAC checks are delivered via proctored check centers and should be scheduled in strengthen.GIAC certification makes an attempt might be activated on your GIAC account after your software has been accepted and in accordance with the phrases of your buy. particulars on birth might be offered along with your registration confirmation upon fee. you'll receive an email notification when your certification attempt has been activated to your account. You could have a hundred and twenty days from the date of activation to comprehensive your certification effort. GIAC tests should be proctored through Pearson VUE. Please click here link for guidance on a way to agenda Your GIAC Proctored exam http://www.giac.org/counsel/schedule_proctored_exam.pdf. GIAC assessments are delivered online through a typical net browser.

    links


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    LPIC-3 Exam 300: Mixed Environments, version 1.0

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    A revolutionary treatment for allergies to peanuts and other foods is going mainstream—but do the benefits outweigh the risks? | killexams.com real questions and Pass4sure dumps

    Jacob Kingsley, 12, visits a bakery that was off-limits before he began oral immunotherapy for a peanut allergy.

    MADDIE MCGARVEY

    Jacob Kingsley was 9 years old when he was handed the poison he'd shunned since before he could walk and told to swallow it as medicine. Obediently, he gulped down a few micrograms of peanut flour—less than 1/1000 of a peanut—diluted in grape Kool-Aid. His mother and a nurse hovered, ready to inject him with epinephrine if an itchy throat and wheezing struck.

    Jacob's mother, Jennifer Kingsley, had driven him 2 hours from their home in Columbus to this doctor's office in Cincinnati, Ohio, for the first of dozens of sessions of peanut immunotherapy. Giving Jacob gradually increasing doses of peanuts, she hoped, would desensitize his immune system.

    It's a strategy Kingsley hadn't pursued until she reached her breaking point. A year earlier, Jacob had swallowed a handful of popcorn that, unbeknownst to him, was laced with peanut product. He suffered a particularly frightening reaction: two bouts of intense symptoms about 6 hours apart. The incident marked his second peanut-related trip to the emergency room, and Kingsley was terrified that the next encounter could be fatal. "I decided, ‘I can't live like this,’" she says. "I was desperate."

    As Jacob sat through the hourslong appointment in Cincinnati, playing video games and swigging increasing doses of peanut-spiked Kool-Aid, he joined legions of children writing food allergy's next chapter. Today, more than 3000 people worldwide, most of them children, have undergone peanut immunotherapy, with the goal of protecting them if they accidentally encounter the food. Other children are trying immunotherapy for allergies to milk, eggs, and tree nuts. Some, like Jacob, get treatment in allergists' offices, where doctors share protocols informally and in published papers. Other children have enrolled in clinical trials, including those run by two companies racing to introduce a peanut-based capsule or skin patch. Both plan to apply for approval from the Food and Drug Administration (FDA) this year. The agency's blessing would dramatically boost immunotherapy's credibility and reach.

    In a field that for decades has had nothing to offer patients beyond avoidance, immunotherapy marks a seismic shift. As it edges closer to mainstream, "There's mixed feelings, with a whole range of enthusiasm," says Corinne Keet, a pediatric allergist-immunologist at Johns Hopkins Medicine in Baltimore, Maryland. Fear that it might cause harm is mingling with euphoria that children living constrained lives could be set free. Doctors who offer immunotherapy describe families eating in Chinese restaurants for the first time and home-schooled children rejoining their peers.

    Like many medical firsts, the therapy is not perfect. "This is version 1.0," says Brian Vickery, a pediatric allergist-immunologist at Emory University in Atlanta. He has conducted peanut immunotherapy trials and worked for 2 years at Aimmune Therapeutics, headquartered in Brisbane, California, one of the companies whose products are nearing approval. Physicians fret about oral immunotherapy's rigors—treatment must continue indefinitely—and its risks, which include the same allergic reactions it aims to prevent. Last year in Japan, a child suffered brain damage during a trial of immunotherapy for milk allergies.

    Meanwhile, physicians on the front lines are navigating hazy science. No one knows exactly how immunotherapy works or who's most likely to be helped or hurt by it. "For me," Keet says, "it's really not clear for an average child with peanut allergy whether it will make sense to do oral immunotherapy or not."

    Like many who study food allergies, Keet was enticed by their mystery. Animal models are poor. The intensity of allergic reactions varies unpredictably, even in the same person over time. Why one child outgrows an allergy and another doesn't is unknown.

    "This was something we didn't cover much in medical school" in the 1990s, says Matthew Greenhawt, a pediatric allergist-immunologist at Children's Hospital Colorado in Denver. Greenhawt's career trajectory tracks with a surge in food allergies, and these days, he can barely keep up with the stream of affected children who visit his hospital. Today, between 1% and 2% of people in the United States, the United Kingdom, and several other countries are allergic to peanuts—a rate that has roughly tripled since the mid-1990s. Other food allergies, such as those to tree nuts, are also on the rise. What's causing the increase is not well understood.

    Despite rising caseloads, deaths from food allergies remain rare. Precise numbers are hard to come by, and estimates range from fewer than 10 to more than 150 a year in the United States. But even though an affected child is more likely to be struck by lightning than to die of a food allergy, the risk can feel ever-present. Parents never know when their children will happen upon culprit foods and how they'll be affected if they do. "We live in a complex world—people move food all over the place," says David Bunning, a businessman whose two sons, now adults, have multiple food allergies. "The impact on children in terms of their confidence to explore their environment can be extreme." Bunning's family almost never traveled or ate out. At their grandparents' house, the boys were usually confined to one room where food wasn't allowed.

    Bunning now chairs the board of directors at Food Allergy Research & Education (FARE), an advocacy group in McLean, Virginia. Families like his, and the doctors who cared for their children, began to agitate for new treatments about a decade ago. Immunotherapy was the obvious candidate: Injections that desensitize the immune system to pollen, grass, pet dander, and bee venom have been around for decades.

    Whether for an allergy to cats or pistachios, immunotherapy aims to disrupt the cells that swing out of control when faced with an allergen. When a child who is allergic to a food eats it, food proteins cross from the digestive tract into the bloodstream. An antibody called immunoglobulin E (IgE), which is bound to white blood cells called mast cells in tissues, recognizes the culprits. IgE activates the mast cells, which release histamine and other chemicals. In the skin, that response can lead to hives; in the respiratory tract, wheezing; and in the gut, vomiting. The most serious symptoms, such as a swollen throat or a reaction throughout the body, mark anaphylaxis, which is what families fear the most. Allergy shots blunt production of IgE, in part, researchers believe, by boosting levels of certain T cells that prompt a cascade of immune changes.

    Peanuts Fighting fire with fire Eating gradually increasing doses of a foodallergen seems to desensitize the immune system over time. Thousands of children have tried oral immunotherapy, and a capsule to treat peanut allergies might be approved by regulators next year. But there’s anxiety about the strategy’s risks and unknowns. When a child eats a food they’re allergic to, an antibody called immunoglobulin E (IgE) helps touch off events that lead to symp-toms from mild to severe. Symptoms can hit the skin, as shown, and also the gut, the respiratory system, and beyond. Food proteins that trigger a reaction pass through the gut and into the bloodstream. Red bloodcell One symptom: skin hives Ingestion ofcontrolledallergen dose The level of IgE in the blood can drop. Less reactive mast cell Milder reactions on the skin and beyond. Less food protein goes into the bloodstream. What’s an allergic reaction? Months of oral immunotherapy make mast cells less reactive and seem to reduce how much allergen enters the bloodstream. Many children can tolerate more of the food they’re allergic to but must continue treatment indefinitely. About 20% discontinue treatment because of side effects and other reasons. How does treatment work? Reactions include hives, itchy throat, vomiting, and difficulty breathing. Allergy symptoms Hives Wheezing Rapid heartrate Vomiting IgE, which binds to mast cells, alerts these white blood cells. They releasehistamine and other chemicals. Mast cells Immunotherapy leads to more of the IgG4 antibody, which is thought to compete with IgE and prevent mast cells from being activated. IgG4 Scientists think the body produces more of this antibody, which makes it harder for the allergen to pass from the gut into the bloodstream. IgA Children with food allergies have high levels of an antibody, IgE, that recognizes specific allergens. IgE Mast cell membrane Allergen IgE

    C. BICKEL/SCIENCE

    Brief testing decades ago indicated that shots for food allergies weren't safe. So around the mid-2000s, scientists began to feed children the allergen instead. One watershed moment came in 2005, when the National Institutes of Health formed a consortium for food allergy clinical trials. A second was in 2011, when advocates sponsored a symposium at Harvard Medical School in Boston to standardize goals and strategy for the pioneering immunotherapy efforts. About 60 people attended. "The patients were very clear," says Carla McGuire Davis, a pediatric allergist-immunologist at Texas Children's Hospital in Houston. They didn't care about eating a peanut butter sandwich; they wanted protection if they accidentally encountered one. Trialists set their end dose at a couple of peanuts and pressed ahead.

    The results of early clinical trials were promising, says Hugh Sampson, a pediatric allergist-immunologist at the Icahn School of Medicine at Mount Sinai in New York City, who has studied immunotherapy in food allergies for many years. After 6 to 12 months of treatment, he says, about 70% to 80% of patients could handle higher doses of the food than before. Lab data were encouraging, too: Ingesting allergens over time seems to make mast cells less reactive, inhibiting their release of harmful chemicals. The therapy also produces other immunoglobulins: IgG4, which further inhibits mast cell activity, and IgA, which helps keep food allergens from escaping the gut.

    The 2011 conference inspired the founding of the company now called Aimmune, fueled by more than $3.5 million from FARE. A second company, DBV Technologies, based in Montrouge, France, and New York City, expanded a few years later. Aimmune began to develop an oral product, essentially a capsule of powder derived from peanut flour with proteins held to consistent levels. In February, the company announced in a press release the results of a phase III trial involving 496 children and teenagers, with a regimen stepping up every 2 weeks through 11 dose levels. Among the 372 people in the treatment group, about 20% dropped out for various reasons, including side effects. After about a year, 96% of people who completed treatment could consume one peanut with no more than mild symptoms, 84% could tolerate two, and 63% could tolerate at least three.

    DBV's skin patch represents a more conservative strategy: It delivers tiny amounts of peanut protein, the equivalent of one peanut over 3 years. Last year, DBV announced that in its phase III trial of almost 400 patients, after a year, those using the patch could, on average, eat three peanuts over the course of several hours before experiencing clinical symptoms such as vomiting or hives; before the trial, the average was just under one peanut. Outcomes varied substantially from person to person.

    If one or both products are approved by FDA in the coming months, expectations are high that they'll be welcomed: Aimmune is now worth about $1.5 billion on the U.S. stock exchange. In 2016, FARE sold its share in Aimmune for $47 million.

    What people don’t understand is this level of protection fluctuates. … It is not guaranteed, nor is it constant.

    Mimi Tang, Murdoch Children’s Research Institute

    Meanwhile, some doctors embrace another route: offering peanut immunotherapy in their practices. "I can treat 20 patients with $5.95 of peanut flour," says Richard L. Wasserman, a pediatric allergist-immunologist in Dallas, Texas.

    Wasserman ventured into food allergy immunotherapy 11 years ago. He developed a protocol based partly on published case reports and protocols for allergy shots, and he put IVs into his first five peanut allergy patients in case he had only seconds to rescue them from severe anaphylaxis. "When they all sailed through the first day, we stopped doing IVs," he says. "But that's a measure of how concerned I was."

    Wasserman has since treated more than 300 children with peanut allergies and more than 400 with other food allergies. Other practitioners are joining in, among them the Cincinnati allergist whom the Kingsley family sought out: Justin Greiwe at Bernstein Allergy Group. Greiwe joined the practice in 2014, straight out of medical training. "It was a little nerve-wracking at the beginning," he says, because no officially sanctioned oral immunotherapy protocol existed. He took precautionary measures, such as lung testing before every treatment, to help ensure patient safety.

    Some clinicians—and executives at the companies developing products—aren't happy about the doctor's office treatments. "That gives a lot of us pause," says Sampson, who in addition to his academic post is chief scientific officer of DBV. "We're very afraid that if this goes on enough, somebody is going to have an accident or a fatal reaction, and that's really going to change the FDA's viewpoint" about the products in development, he says.

    Wasserman agrees about the need for caution. "Not every practicing allergist should be doing oral immunotherapy," he says. Greiwe suggests the treatment requires a dedicated staff, and he gives every immunotherapy family his cellphone number.

    Jacob was one of Greiwe's first immunotherapy patients. His mother remembers Jacob's ears burning—a minor reaction that subsided on its own. "Or he said he hated peanuts and wanted to quit," she says. Worst was about 6 months in, when Kingsley discovered that for 2 weeks, Jacob had hidden his dose to avoid eating it. That was "the only time we ever felt danger," she says. Stopping treatment can quickly alter the immune system, says Cecilia Berin, an immunologist at Mount Sinai, because immunotherapy requires constant exposure. When Jacob squirreled away his daily dose, the changes induced in his immune system almost certainly started to fade out, putting him at risk. Greiwe restarted him on a lower dose and, his mother says, "We got through it."

    Food allergies are becoming more common, and a handful of foods accounts for the vast majority of allergies. But small doses of the foods can blunt allergic reactions.

    SCIENCE PHOTO LIBRARY/SCIENCE SOURCE

    Even children who faithfully follow instructions face risks. The immune system can react to even subtle pressures, and the list of what can provoke a reaction to treatment is long. Exercising within a couple of hours of the dose can do it; so can a cold, a stomach virus, menstruation, or a hot shower. An asthma attack can trigger a reaction—many children with allergies have asthma as well—and so can stress. "We had a patient who had just played the violin on a stage, came down, and about 15 minutes later … took the dose and had a reaction," Davis says.

    Berin posits that external pressures such as physical activity or illness make the gut more permeable, pushing more of the immunotherapy dose into the bloodstream. But that remains hypothesis. Regardless, it's becoming clear that "there are people who react years down the road to a maintenance dose," Keet says. For Jacob, such a moment came 9 months in. One evening while watching a movie, he downed his peanut M&M's and later ran outside with his cousins to dance in a rainstorm. He broke out in hives head to toe. Kingsley dialed Greiwe's number, and Jacob got a double dose of an allergy medication.

    The most tragic data point to date is the case in Japan. A child had enrolled in a trial of immunotherapy for milk allergies at the Kanagawa Children's Medical Center in Yokohama. He'd raised what he could ingest from less than 8 milliliters to 135 milliliters—about half a glass of milk. After 3 months on that maintenance dose, he swallowed it and soon complained of pain. Within minutes, he had stopped breathing. His heartbeat was later restored in the emergency room, but he'd gone too long without it and sustained severe brain damage, according to a statement from the hospital's president, Sumimasa Yamashita, in November 2017. Kanagawa Children's Medical Center declined to comment, saying only that the incident remains under investigation.

    In its statement, the hospital noted the boy had suffered an asthma attack the day before the catastrophic dose. He also was on a protocol that aimed to rapidly escalate the volume of milk he could drink over less than 3 weeks. But why the child reacted so disastrously to that glass of milk is unknown.

    "What people don't understand is this level of protection fluctuates," says Mimi Tang, a pediatric allergist-immunologist at Murdoch Children's Research Institute in Melbourne, Australia. "It is not guaranteed, nor is it constant."

    One of the few long-term analyses was published in 2013 in The Journal of Allergy and Clinical Immunology. Keet, pediatric allergist-immunologist Robert Wood at Johns Hopkins Medicine, and their colleagues sought out 32 children who'd been in a milk immunotherapy trial. Three to 5 years later, "The results were surprising in a sobering kind of way," Wood says. Only about a quarter "were doing great … tolerating unlimited quantities of milk without side effects." Another quarter had abandoned the protocol and returned to strict avoidance. The rest were eating dairy products inconsistently, with intermittent or even frequent allergic reactions. "It's hard to know which comes first, whether they got complacent" about ingesting it "or backed off because [they were] having too many symptoms," Wood says.

    It made me nervous, really nervous, to put something in my daughter’s mouth that she was allergic to.

    Divya Balachandar, mother of Leena Wong

    More and more families are willing to live with those uncertainties because the alternative is greater anxiety. "We were scared senseless," says Divya Balachandar, whose daughter Leena Wong, now 7 years old, had her first episode of anaphylaxis at age 4 after being touched by a cashew. Testing revealed Leena also was allergic to sesame, eggs, milk, other tree nuts, and peanuts. Balachandar, a pediatric pulmonologist in New York City, and her husband enrolled Leena in a federally funded oral immunotherapy trial for peanut allergy in 2015. "It made me nervous, really nervous, to put something in my daughter's mouth that she was allergic to," Balachandar says. She gravitated toward a trial over treatment with a local allergist because, she says, "there were no rules" about how to treat in private practice. By this spring, Leena could eat two spoonfuls of peanut butter—about 25 peanuts—without a problem. She started second grade sitting with her classmates at lunchtime, liberated from a separate nut-free table.

    Both companies developing peanut-based treatments say they had more volunteers for their trials than they could accommodate. Private practitioners usually have a waiting list; Greiwe's runs more than 4 months. At Stanford University in Palo Alto, California, which has a large food allergy research program, more than 2000 patients are waitlisted to enroll in the university's clinical trials, says Sharon Chinthrajah, an allergist-immunologist there.

    More treatments are on the horizon. In Australia, Tang is working with a company that's testing an approach she pioneered, a combination of a probiotic and oral peanut immunotherapy. The probiotic should tilt the body toward producing the subset of T cells that tolerate the allergen and away from making cells that attack it, she says. Chinthrajah and others are enthusiastic about combining oral immunotherapy with a monoclonal antibody called omalizumab, which is FDA approved to treat allergic asthma. Clinical trials are also gearing up to test other monoclonal antibodies that target molecules involved in allergic inflammation.

    Jacob's and Leena's families are eager to see what comes next. Jacob is also allergic to pistachios and cashews, but because he finds those foods easier to avoid than peanuts, the family has rejected immunotherapy that targets them. Leena's family is the opposite. With her older sister and her parents, Leena attends Indian functions regularly, where tree nuts are a common ingredient in sauces. In August, another episode of anaphylaxis landed her in the emergency room: She began to vomit and suffered chest tightness and eye swelling after eating Indian food her parents suspect contained cashews—despite having triple-checked with the restaurant that it did not. "I would love to do tree nuts," Balachandar says, once immunotherapy "becomes more available and better understood."

    Physicians with deep roots in food allergy immunotherapy hope those new to it tread carefully. Doctors who offer such treatments "have to know the data cold," including published results and side effects that may crop up, Greenhawt says. Still, he's thrilled that peanut immunotherapy treatments may soon be approved. The other day, talking with a peanut-allergic 4-year-old and his mother, Greenhawt shared what the next year might bring. "I said, ‘I'm going to see you a year from now; hopefully, we will have two products that are approved, and we can talk about which one might be best for you.’" The mother looked startled and delighted, Greenhawt says. "I've never seen somebody smile as brightly as that."


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    Top 5 | Linux Certifications in 2018 | killexams.com real questions and Pass4sure dumps

    1. LPIC (Linux Professional Institute Certification)

    Started back in 1999 by Linus Torvalds, these Linux certifications today has become important for any Linux professional. This program is available in Four distinct levels, which are:

    LPI : Linux Essentials Certification

    The Linux Essentials Professional Development Certificate (PDC) also serves as an ideal stepping-stone to the more advanced LPIC Professional Certification track for Linux Systems Administrators.

    Current Version: 1.5 (Exam code 010–150)

    Prerequisites: There are no prerequisites for this certification

    Requirements: Passing the Linux Essentials 010 exam

    Validity Period: Lifetime

    Languages: English, German. The exam may be written in the following languages only at paper-based exam events: Portuguese (Brazilian), Italian, Spanish (Modern), Chinese (Simplified), Chinese (Traditional)

    To receive the Linux Essentials Certificate the candidate must:

  • have an understanding of the Linux and open source industry and knowledge of the most popular open source Applications;
  • understand the major components of the Linux operating system, and have the technical proficiency to work on the Linux command line; and
  • have a basic understanding of security and administration related topics such as user/group management, working on the command line, and permissions.
  • LPIC- 1: Linux Administrator Certification

    LPIC-1 is the first certification in LPI’s multi-level Linux professional certification program. The LPIC-1 will validate the candidate’s ability to perform maintenance tasks on the command line, install and configure a computer running Linux and configure basic networking.

    The LPIC-1 is designed to reflect current research and validate a candidate’s proficiency in real world system administration. The objectives are tied to real-world job skills, which we determine through job task analysis surveying during exam development.

    Current Version: 4.0 (Exam codes 101–400 and 102–400)

    Prerequisites: There are no prerequisites for this certification

    Requirements: Passing exams 101 and 102

    Validity Period: 5 years

    Languages: English, German, Italian, Portuguese (Brazilian), Spanish (Modern), Chinese (Simplified), Chinese (Traditional) and Japanese

    To become LPIC-1 certified the candidate must be able to:

  • understand the architecture of a Linux system;
  • install and maintain a Linux workstation, including X11 and setup it up as a network client;
  • work at the Linux command line, including common GNU and Unix commands;
  • handle files and access permissions as well as system security; and
  • perform easy maintenance tasks: help users, add users to a larger system, backup and restore, shutdown and reboot.
  • LPIC- 2: Linux Engineer Certification

    This is an advanced level Linux Certification, which requires an active LPIC-1 certification. It has two exams- First covers the file system and devices, kernel, system startup, network configuration, system maintenance, storage administration, and even capacity planning and the second exam covers email services, network client management, domain name servers, system security and troubleshooting.

    LPIC-2 is the second certification in LPI’s multi-level professional certification program. The LPIC-2 will validate the candidate’s ability to administer small to medium–sized mixed networks. The candidate must have an active LPIC-1 certification to receive LPIC-2 certification, but the LPIC-1 and LPIC-2 exams may be taken in any order.

    Current Version: 4.5 (Exam codes 201–450 and 202–450).

    Prerequisites: The candidate must have an active LPIC-1 certification to receive LPIC-2 certification, but the LPIC-1 and LPIC-2 exams may be taken in any order

    Requirements: Passing exams 201 and 202

    Validity Period: 5 years

    Languages: English, German, Japanese

    To become LPIC-2 certified the candidate must be able to:

  • perform advanced system administration, including common tasks regarding the Linux kernel, system startup and maintenance;
  • perform advanced Management of block storage and file systems as well as advanced networking and authentication and system security, including firewall and VPN;
  • install and configure fundamental network services, including DHCP, DNS, SSH, Web servers, file servers using FTP, NFS and Samba, email delivery; and
  • supervise assistants and advise management on automation and purchases.
  • LPIC- 3: Linux Enterprise Professional Certification

    It is a senior-level Linux certification, which needs an active LPIC-2 besides passing any single exam in the 300 series. This certification includes exam IDs, which are:

  • 300: Mixed Environment
  • 303: Security
  • 304: Virtualization and High Availability
  • 300: Mixed Environment covers Samba, work with Linux & windows client, and even plus OpenLDAP.

    303: Security covers operations, application security, and the network are covered under the security exam besides cryptography and access controls.

    304: Virtualization and High Availability covers virtualization and high availability cluster storage and engagement.

    Current Version: 1.0 (Exam code 300–100)

    Prerequisites: The candidate must have an active LPIC-2 certification to receive LPIC-3 certification, but the LPIC-2 and LPIC-3 exams may be taken in any order

    Requirements: Passing the 300 exam

    Validity Period: 5 years

    Languages: English, Japanese

    2. CompTIA Linux+

    CompTIA Linux+ covers common tasks in major distributions of Linux, including the Linux command line, basic maintenance, installing and configuring workstations, and networking.

    Let’s know more about these two Linux certifications here:

  • CompTIA Linux Certification (LX0–103) — Explained
  • This test covers these few domains, which are:

  • GNU and UNIX Commands
  • System Architecture
  • Linux Installation and Package Management
  • Devices, Linux Filesystems, Filesystem Hierarchy Standard
  • 2. CompTIA Linux Certification (LX0–104) — Explained

    This test covers these few domains, which are:

  • Security
  • Shells, Scripting, and Data Management
  • User Interfaces and Desktops
  • Administrative Tasks
  • Essential System Services
  • Networking Fundamentals
  • Exam Details

    Exam Description: Linux+ is comprised of two exams — LX0–103 and LX0–104. Candidates must pass LX0–103 before taking LX0–104. Both test Have:-

    Number of Questions: 60 questions

    Type of Questions: Multiple Choice (Single Response), Multiple Response and Fill-in-the-Blank

    Length of Test: 90 Minutes

    Passing Score: 500 (on a scale of 200 to 800)

    Recommended Experience: CompTIA A+, CompTIA Network+ and 12 months of Linux admin experience

    Languages: English, German, Portuguese, Spanish

    Price: $206 USD (See all pricing)

    3. RHCE (Red Hat Certified Engineer)

    The Red Hat Certified Engineer (RHCE) is a certification you can earn to become a Red Hat Certified System Administrator (RHCSA). The RHCE certification shows that you have demonstrated the knowledge, skill and ability required of senior system administrator responsible for Red Hat Enterprise Linux systems.

    In case, you have earned RHCE, you become eligible for RHCA (Red Hat Certified Architect) credentials including:

  • RHCA: Application development
  • RHCA: Datacenter
  • RHCA: Cloud
  • RHCA: DevOps
  • RHCA: Application platform
  • 4. Oracle Linux

    Certifications comprise of two exams, which are:

  • OCA- 1Z0–100 Oracle Linux 5 and 6 System Administration, needs 61% to pass, and 80 questions to attempt
  • OCP- 1Z0–105 Oracle Linux 6 Advanced System Administrator, requires 61% to pass, and has a total of 97 questions.
  • 5. GIAC Certified UNIX Security Administrator (GCUX) Description

    GIAC Certified UNIX System Administrators (GCUXs) have the knowledge, skills and abilities to secure and audit UNIX and Linux systems.

    Target

    Individuals responsible for installing, configuring, and monitoring UNIX and/or Linux systems.

    *No Specific training is required for any GIAC certification. There are many sources of information available regarding the certification objectives’ knowledge areas. Practical experience is an option; there are also numerous books on the market covering Computer Information Security. Another option is any relevant courses from training providers, including SANS.*

    Requirements
  • 1 proctored exam
  • 75 questions
  • Time limit of 2 hours
  • Minimum Passing Score of 68%
  • Renew

    Certifications must be renewed every 4 years. Click here for details.

    Delivery

    NOTE: All GIAC exams are delivered through proctored test centers and must be scheduled in advance.GIAC certification attempts will be activated in your GIAC account after your application has been approved and according to the terms of your purchase. Details on delivery will be provided along with your registration confirmation upon payment. You will receive an email notification when your certification attempt has been activated in your account. You will have 120 days from the date of activation to complete your certification attempt. GIAC exams must be proctored through Pearson VUE. Please click the following link for instructions on How to Schedule Your GIAC Proctored Exam http://www.giac.org/information/schedule_proctored_exam.pdf. GIAC exams are delivered online through a standard web browser.

    Links


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