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LOT-828 - Administering IBM Workplace Services Express 2.6 - BrainDump Information

Vendor Name : IBM
Exam Code : LOT-828
Exam Name : Administering IBM Workplace Services Express 2.6
Questions and Answers : 86 Q & A
Updated On : November 15, 2018
PDF Download Mirror : LOT-828 Braindumps
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LOT-828 exam Dumps Source : Administering IBM Workplace Services Express 2.6

Test Code : LOT-828
Test Name : Administering IBM Workplace Services Express 2.6
Vendor Name : IBM
Q&A : 86 Real Questions

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IBM Administering IBM Workplace Services

Is Nagios The future of Monitoring For IBM i? | killexams.com Real Questions and Pass4sure dumps

November 12, 2018 Alex Woodie

For decades, expertise experts became to based frameworks from IBM Tivoli, CA, Hewlett Packard, and BMC (“The large four”) to video display their hardware and software stacks. but the open source world has caught up with those closed monitoring environments, and a mission dubbed Nagios is poised to be the go-to platform for IT monitoring, together with on IBM i.

Nagios, in case you aren't general, is a free and open source software product that offers monitoring and alerting for servers, community apparatus, purposes, and the array of capabilities that businesses more and more depend on. The software –backed by way of the necessary recursive acronym “Nagios Ain’t Gonna Insist On Sainthood” – turned into at the beginning developed by way of Ethan Galstad lower back in 2002 to run and display screen Linux methods, which changed into just beginning to make headway in enterprise information centers.

through the years, the C-primarily based application has been prolonged to support an array of object types, together with host resources like processor load, disk and RAM utilization, and equipment logs for a majority of regularly occurring working programs, together with IBM i. The vigorous Nagios neighborhood has created a wide array of Nagios agents that have prolonged the framework to an estimated 5,000 contraptions.

Nagios is an open source device that allows directors to computer screen their IT gear and applications.

On the community aspect of things, Nagios Core (because the open source product is popular) monitors routers, switches, and different equipment, and helps SMTP, POP3, FTP, and SNMP protocols, amongst others. All far flung monitoring can also be encrypted, and it additionally offers a plug-in that lets users create their personal monitors in loads of languages.

information collected with the aid of active and passive Nagios plug-ins is routed into the Nagios server, where the records is sorted and alerts are sent out. clients can eat signals in a whole lot of ways, including via an internet browser, through SMS pagers, and through e mail. With a simple glance on the Nagios dashboard on a mobilephone, a techniques admins can see if crucial servers, method, and functions are alive or useless.

The Nagios Core server software can also work with a “circular-robin database” (RRD) to simplify the storage and querying of time-series records. With RRD, admins can dive deeper into Nagios records and look at graphs to see performance trends. And with a little setup ahead of time, Nagios can also be configured to immediately reply to pursuits as they happen, or expand signals to different individuals.

organizations that desire more than what Nagios Core has to present can locate it from Nagios organisations, the commercial outfit behind the open source project. The St. Paul, Minnesota-based mostly business, which employs Galstad, extends Nagios Core with a few choices, together with Nagio XI, which elements a more extensible front-end and a MySQL-based mostly lower back-end. Nagios XI also brings a better consumer journey with more powerful graphs and more advantageous dashboards.

IBM i valued clientele can use Nagios to computer screen 15 metrics with the Nagios Plug-Ins for IBM i beta.

sadly, Nagios corporations doesn’t guide IBM i. however that you would be able to get a Nagios distribution for IBM i from a little outfit known as foreign company Machines. In 2017, massive Blue shipped a beta edition of an IBM i plug-in designed to feed information from the IBM i sever into the open source Nagios Core product or Nagios XI.

according to a developerWorks web page, the IBM i Nagios plug-in collects 15 different records points from IBM i servers, together with issues like CPU and disk utilization, ASP usage, number of active jobs, and lengthy-running SQL jobs, amongst others. Some of those services are supported by means of SNMP, while others require the open source JTOpen Java toolbox to be installed.

The Nagios server itself doesn’t run on IBM i – at the least now not yet. With the Nagios on IBM i plug-in, IBM gives users with guidance on a way to set up Nagios Core or Nagios XI on a Linux server. Technically, there should still be nothing stopping from a consumer installation Nagios in a Linux LPAR on the vigour systems server – or even for IBM to port the application to the IBM i OS by way of PASE – however that has no longer came about yet.

IBM makes the case for IBM i retail outlets to use Nagios in a PDF presentation on Nagios created by means of IBM i business architect Tim Rowe and Wang Yun, who developed the Nagios for IBM i plug-in. while Navigator for i provides first rate coverage of IBM i-centric queues and metrics, that product doesn’t deliver valued clientele with any visibility of what’s happening backyard the IBM i equipment.

customers who purchase Nagios XI can display screen IBM i metrics graphically.

Nagios, then again, offers administrators and operators with a single centralized view of all IT assets, Rowe and Yun write. besides the core IBM i metrics that at the moment are accessible by means of the Nagios plug-in, IBM i users can get vogue and ancient records, as neatly as the flexibility to configure metrics to their liking, now not to point out the skill to create their personal custom plug-ins.

IBM isn’t the most effective business doing Nagios work on IBM i. a few years in the past, ShapPin Cheng launched a GitHub assignment referred to as check_as400 that moved statistics from IBM i server logs into Nagios. since the extensibility and openness of Nagios, it wouldn’t be striking to peer independent application companies within the IBM i community undertake the technology for their personal methods monitoring choices.

For now, IBM presents the Nagios plug-in as a beta. Don’t be shocked to look it turn into a completely supported providing within the months to come, exceptionally for the reason that the love affair that IBM has with open source software nowadays.

linked reports

IBM i performance secrets and techniques published

What’s Cooking With IBM i On GitHub?

ASCI Job Scheduler gets Hooks for Nagios


How IBM and crimson Hat Will impact Your Cloud method | killexams.com Real Questions and Pass4sure dumps

Barring a heavy-handed strategy to the contemporary acquisition, IBM and red Hat can do some stunning things in the market.

IBM is an extended way from making actual machines. That a part of the enterprise went with Lenovo several years in the past. So, what has been their focal point ever considering the fact that? software and functions. And, among these application items and capabilities has been the cloud.

except these days, you may additionally have heard little about IBM’s cloud presence. youngsters i can guarantee you it’s there, it become definitely struggling to compete with the likes of AWS, Azure, and even GCP. Now, with predictions like those from Gartner stating that by using 2020, 90% of companies will adopt hybrid infrastructure management capabilities and that the market in universal may be worth $240 billion or extra – this turned into pretty much as good a time as any to in reality take a dive into the cloud administration and delivery ecosystem.

Image: Shutterstock

picture: Shutterstock

And IBM really took the plunge. basically, this became the largest acquisition or deal that IBM has ever gambled on throughout its 107-year existence. In figuring out the expertise they just took under their massive Blue wings, it might actually repay.

What this means for IBM, pink Hat, and your cloud

Let’s beginning with IBM. It’s been a difficult journey for this organization. as soon as familiar for consistent growth and innovation, IBM has been struggling when it comes to keeping up with fundamental business avid gamers. This stagnation changed into new and truly uncomfortable for IBM’ers and lovers alike. So, what to do? purchase a magnificent, multinational, open-supply software business that’s been setting up some leading options. This contains pink Hat enterprise Linux, middleware answer JBoss, CloudForms, and the very powerful cloud and container management device – OpenShift.

For IBM, this capability opening the aperture into a quick-paced and starting to be hybrid cloud market. Most of all, this means concentrated on business purchasers and arming them with main tools around cloud management. truly, using one of the business’s top of the line container administration solutions (OpenShift) will provide IBM consumers the styles of tools and features to strategy digital transformation efforts in addition to total technology modernization shifts.

The total proposal of "monolith to microservices" may also be encompassed by way of this IBM+crimson Hat deal. expertise like OpenShift will supply IBM a leading Kubernetes management platform able to offering actual-world cloud-native solutions. This isn’t simply IBM paperware any more, with pink Hat, the ammunition is fully there. combine this with a much bigger portfolio of middleware and powerful cloud-equipped (and validated) developer tools and you have a extremely effective story for hybrid cloud deployment and administration.

“With IBM’s fresh circulation to containerize its middleware, today’s landmark partnership between IBM and crimson Hat provides shoppers with greater alternative and suppleness. Our general vision for hybrid cloud the usage of container architectures allows tens of millions of enterprises – from banks, to airways, to executive organizations - to access leading expertise from both groups without having to make a choice from public and personal cloud.”

- Arvind Krishna, Senior vice chairman, IBM Hybrid Cloud

For IBM, purple Hat (and OpenShift) is an instantaneous gateway into a developer group that’s literally designing the architecture for commercial enterprise businesses and their hybrid cloud initiatives. Did IBM pay a top rate for purple Hat? You more desirable accept as true with it. changed into it value it? Time will tell. Coming from in the back of isn't convenient, however this is a great manner to position a turbo engine in your cloud company.

For crimson Hat, there are relatively huge merits, too. aside from the large quantities of materials and scale capabilities, crimson Hat is entrenching itself even additional into an enterprise market that’s primed and competent for the cloud. Now, think about leveraging purple Hat equipment to impact all of these unbelievable IBM shoppers which have been itching for an IBM-equipped hybrid cloud structure.

“by means of extending our long-standing collaboration with IBM, we’re bringing together two leading commercial enterprise application structures in pink Hat OpenShift Container Platform and IBM Cloud inner most and adding the power of IBM’s application and cloud options.”

- Paul Cormier, President, items and technologies, purple Hat

in response to a recent purple Hat observation, in the course of the acquisition, IBM and red Hat purchasers can now:

  • Maximize their current know-how investments and move them extra comfortably to the hybrid cloud with IBM Cloud inner most and crimson Hat OpenShift serving as the regular basis;
  • construct and installation containerized applications on one single, integrated container platform IBM Cloud deepest proposing a single view of all commercial enterprise information;
  • enable developers to design, modernize, and set up new applications more quickly while taking potential of IBM’s cloud-primarily based services corresponding to synthetic intelligence (AI), web of things (IoT) and blockchain with IBM Cloud deepest on red Hat OpenShift Container Platform.
  • “joining forces with IBM,” referred to purple Hat CEO Jim Whitehurst, “will supply us with a stronger level of scale, supplies and capabilities to accelerate the impact of open supply because the foundation for digital transformation and convey purple Hat to a good wider audience, all whereas conserving our enjoyable lifestyle and unwavering commitment to open supply innovation.”

    here's the place I need to pump the brakes, simply somewhat. I in reality hope that IBM doesn’t go heavy-surpassed in trying to change pink Hat’s market definition and subculture. as a result of if it tries to push crimson Hat to undertake a broader IBM cultural and company model, I don’t in reality see it ending smartly. Plus, I’m bound there at the moment are additional considerations from existing purple Hat customers: What’ll ensue to RHEL? How does this have an impact on licensing and the equipment that i take advantage of? Do I deserve to study rivals like Pivotal or other options like Cloud Foundry? once again, time will inform how this can all play out. My hope is for an easy integration, while maintaining purple Hat simply as brilliant as it is today.

    ultimately, it’s essential to have in mind what this could mean in your hybrid cloud and common cloud management answer. Barring a heavy-exceeded approach to this acquisition, IBM and purple Hat can do some truly impressive issues out there. here's actually the primary time in a very long time that IBM pushed itself into the forefront of cloud, container, and hybrid cloud innovation. The pleasing half is how IBM will combine other solutions, Watson for example, into red Hat items. If achieved appropriate, there may also be lots of merits for the consumer, companies, and the cloud in typical. I’m staying positive.

    invoice is an enthusiastic technologist with event in quite a lot of industries. This includes facts core, cloud, virtualization, security, AI, mobility, aspect solutions, and a good deal more. His structure work comprises giant virtualization and cloud deployments as well as ... View Full Bio We welcome your feedback on this subject matter on our social media channels, or [contact us directly] with questions in regards to the web page.

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    Administering IBM Workplace Services Express 2.6

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    Franklin Covey Company (FC) CEO Bob Whitman on Q4 2018 Results - Earnings Call Transcript | killexams.com real questions and Pass4sure dumps

    No result found, try new keyword!I also wanted to express what a privilege it is to work with our more than ... that particular initiative. We have services that we provide in the form of administering their implementation ...

    How to effectively work with multiple cloud providers | killexams.com real questions and Pass4sure dumps

    Businesses have multiple cloud providers from which to choose. Amazon Web Services is the 800-pound gorilla, but...

    Microsoft Azure offers an increasingly competitive set of services. The Google Cloud Platform is attractive to those with big data and processing needs that can use Google's infrastructure. IBM and Rackspace offer alternatives to the big three.

    Businesses may not want to be tied too closely to a single cloud provider. Specialized services available in one cloud aren't always available in another. In other cases, various departments within an organization may have developed services on different platforms, requiring centralized cloud management teams to support environments hosted by multiple providers.

    There are strategies and techniques for working with multiple cloud providers in ways that take advantage of the benefits while limiting duplication of effort and other extra work. To sort through this, we'll examine the core services: compute and workload management, storage services, data management and security.

    Next, we'll consider how the concept of infrastructure as code is a key enabler of multicloud management. Container services are described as a common layer of abstraction across clouds that will help further ease the burden of managing applications across multiple clouds.

    Compute and workload management services

    Compute and workload management services include orchestration, cluster management and configuration tools.

    For starters, virtual machines (VM) are the building blocks of any compute service. Infrastructure as a service cloud vendors offer a variety of VMs, and it's important to understand their differences. The specifications of a given VM will include an OS, processing power, memory and features for network optimization. Microsoft, Google and Amazon Web Services (AWS) also offer specialized clusters designed for big data and analytics workloads supporting, for example, Hadoop and Apache Spark.

    There are strategies and techniques for working with multiple cloud providers in ways that take advantage of the benefits while limiting duplication of effort and other extra work.

    Container services are also becoming increasingly important. Containerization is well suited to deploying microservices, and, in many cases, can be more efficient than running individual VMs for each application. Containers offer lightweight virtualization on a Linux foundation and can be used with standard tools, such as Docker. As for cluster management, Apache Mesos and Docker Swarm are tools worth considering. Mesos lends itself to job scheduling, as Marathon and Chronos are both supported. And Mesos supports the Docker Swarm API, so you can run Swarm in Mesos if need be.

    Also falling under the umbrella of compute and management services is orchestration. Orchestration features allow system admins to define infrastructure as code and automate code deployment.

    Orchestration is particularly important for organizations that require scaling or that run across multiple clouds. For multicloud use, configuration and orchestration tools, such as Chef and Puppet, are important. Vendor-specific tools, such as AWS CloudFormation, may also be options.

    When deciding between first- and third-party tools, keep in mind the tradeoffs. Third-party tools offer more cross-cloud flexibility and allow for moving workloads across clouds. On the other hand, a vendor's own tools will be purpose-built to work within the given vendor's cloud.

    Storage services

    Moving workloads across multiple clouds is challenging if you need to coordinate them between clouds or run scripts designed to use one cloud's API on a competing cloud's platform. Storage, however, poses a different kind of problem. While all of the major cloud vendors offer object storage services, it is important to understand the more subtle differences between options. To optimize costs and performance, you may want to choose object storage based on the duration for which the data will be stored, durability requirements, latency in saving and retrieving data and proximity to compute resources.

    For example, AWS offers Simple Storage Service (S3) for object and elastic block storage for file system storage on VMs. S3 object storage comes in at a lower cost, but has a higher latency and is not suitable for a file system. Google, on the other hand, offers near-line storage at a low cost that's suitable for file systems. Be aware that near-line storage has a higher latency. If you are looking for archival storage, it may make sense to choose a single cloud provider to keep storage management to a minimum. If redundancy is important, though, you may want to consider archiving on multiple clouds.

    Proximity to computing is another key consideration. In general, data should be as near to computation resources as possible. This will increase performance and, as a result, cut costs. Additionally, copying data out of a cloud will often incur egress charges, so it may make sense to keep compute jobs in the same cloud that generates the data.

    Data management

    Data management entails using relational and non-relational -- also known as NoSQL -- database offerings for managing structured and semi-structured data. To manage data, there are two options: use a database as a service (DBaaS) or manage your own database. When deciding, you'll want to consider how you will store data, the physical location of the data, what level of latency this entails and the environment's durability. Additionally, be aware of the costs involved if you move the data in the event the vendor or storage method doesn't work out.

    Using a DBaaS tightly couples database operations to a single vendor, although this isn't necessarily a bad thing. One option is AWS' DynamoDB, which is well suited for key value and document data stores. It offers low latency and configurable consistency with virtually no database administration overhead. It does, however, employ a proprietary database that's unavailable from other vendors. Using proprietary database tools such as DynamoDB can stretch operations staff thin if you need proprietary services with multiple clouds.

    When using multiple cloud providers, your best option is most likely to manage your own databases. While this sounds like a costly chore, orchestration tools can help. These tools make managing your own data store more effective across clouds if you script configurations for databases. An advantage of using multiple cloud providers is that you can store backups across clouds, thus enabling a multivendor, cloud-based disaster recovery strategy.

    Regardless of which data management method is chosen, always keep data governance in mind. Where the data is stored can affect how it needs to be treated and secured. Safe Harbor is gone, so consider using another regulation, such as HIPAA, as a guideline, and plan for data storage strategies based on geography.

    The abstraction and security questions

    Vendor-specific tools can lock you out of some of cloud computing's flexibility. Still, there are ways to get around this issue and decouple your resources from vendor-specific platforms. Certain tactics will hide implementation details of specific cloud vendors. For example, you could use thin layers of abstraction for common functions, such as object store.

    This would entail using a cross-cloud API such as Apache Libcloud. Libcloud is an open source Python API that enables users to interact with a variety of cloud providers. The API is supported by AWS Elastic Cloud Compute and S3 instances, as well as Google Compute Engine and Rackspace. Supported Python versions include 2.5, 2.6, 2.7, PyPy and Python 3.

    Use specialized services, such as AWS Lambda, sparingly. Consider implementing functions you would run in Lambda in Docker containers instead. Containers are commonly available across clouds.

    If you plan to decouple from a single vendor, it is recommended you run your own services. This is particularly true for databases. However, always take cost into consideration; a DBaaS may end up saving you money in the long run.

    Security becomes more challenging when using multiple cloud providers because you have to implement multiple versions of the same controls across clouds. For example, instead of implementing multiple directories, implement one directory and make it available via federation to multiple clouds. Use a common infrastructure, such as LDAP or Active Directory, as much as possible. As for enforcing policies across clouds, third-party services and tools are indispensable.

    For complex identity management tasks, consider third-party services such as Ping Identity. Ping Identity offers a number of tools that are spread across platforms, such as multifactor authentication and user identity management.

    For security log management, a strong third-party option is Loggly, which uses open source protocols, and so is compatible with multiple cloud providers. The tool reads and consolidates a number of text-based log types, including Ruby, Java, Python, PHP and MySQL, among others. Alert Logic offers a full suite of security tools with its Cloud Defender product. Cloud Defender collects security data, enables security data analytics and can perform threat analysis.

    Managing infrastructure as code

    When it comes to making effective use of multiple clouds, managing infrastructure as code is a good place to start. Software developers have created sophisticated techniques and tools for managing multiple versions of frequently changing code. These tools and practices can be used to manage infrastructure when using declarative specifications. Follow practices that require any resource deployed to the cloud to be done in a scripted manner. If all goes well, system admins should not be manually adding and removing resources or changing configurations; this should be done through scripts that are deployed using either third-party or proprietary tools.

    This mentality stretches beyond code deployment. Admins can take advantage of third-party services to make better use of multiple clouds. A cloud service brokerage, which serves as an intermediary between a cloud provider and the user, is one such service worth considering. Another option is cloud aggregation tools for integration between clouds to facilitate workload management and cost management tools.

    There are no hard and fast rules for working with multiple cloud providers, but there are practices that will limit the duplication of work, difficult migrations and security vulnerabilities.


    Drugmakers Lobby Trump Administration To Halt Discounts For Seniors | killexams.com real questions and Pass4sure dumps

    News outlets report on stories related to pharmaceutical pricing.

    Bloomberg: Pharma Makes Lobbying Push To Roll Back Seniors' Drug Discounts  Pharma giants have been quick to tout their efforts to help the Trump administration rein in runaway drug prices, but behind the scenes the industry has been lobbying furiously to roll back recently mandated medicine discounts for U.S. seniors. Drug companies are focusing lobbying efforts to use a possible lame-duck session of Congress to peel back a legislative loss they suffered earlier this year, according to people familiar with the efforts. On the line for the drug industry is $1.9 billion next year, according to one estimate. Critics say the effort by the industry has the potential to increase costs for some of the most vulnerable and medically fragile Americans: seniors on Medicare. (Koons and Brody, 11/5)

    Stat: AMA Delegates To Weigh A Plan For Personal Importation Of Drugs From Canada The nation’s largest group of physicians is wading into the debate over the cost of prescription drugs with a proposal to allow Americans to purchase medicines from Canada, but not by going online. At its semi-annual policy meeting that begins this coming weekend, the American Medical Association will consider a motion to endorse medicines that are obtained in person from licensed brick-and-mortar Canadian pharmacies, but only if there are limits on quantities and product safety assurances are in place. (Silverman, 11/6)

    FiercePharma: Epidiolex Rollout: $32,500 List Price Spurs Critics As First Cannabis Drug Hits Shelves It’s official—the first FDA approved CBD product is on the market. GW Pharmaceuticals announced this morning that its cannabinoid Epidiolex, approved in the treatment of two rare forms of epilepsy, is now available by prescription. However, it may already be facing its first stumbling block with its price tag. Epidiolex has racked up angry social media comments since August when it announced its list price as $32,500 per year—with a new surge following today’s news. GW Pharma has been quick to point out that the drug is a rare disease therapy specifically approved to treat seizures associated with Lennox-Gastaut and Dravet syndromes, and its pricing is in line with similar FDA-approved anti-epileptics. (Bulik, 11/2)

    Stat: Despite Scrutiny Of Patient Assistance Programs By The Feds, Pharma Appears Unprepared  As the federal government scrutinizes various programs that provide some form of assistance to patients, drug makers are responding inconsistently to the legal hazards, according to a new survey. Approximately one-third of the companies queried say they have altered procedures for funding independent charities that provide financial assistance to patients, but very few are regularly monitoring or auditing the activities of their patient services teams. And 25 percent of drug makers report that they provide patient services, such as copay cards, to people using their medicines for unapproved uses. (Silverman, 11/6)

    FiercePharma: Tale Of 2 CEOs: Merck Chief Treads Carefully On Pricing, While Pfizer's Read Predicts More Hikes Two Big Pharma CEOs have sounded off on drug pricing, and what a difference between the two. Merck's Ken Frazier stayed in safe territory with his barbs against rebates, but Pfizer's Ian Read touched off controversy by predicting a return to price hikes. During separate sets of remarks this week, Frazier took a line that's approved even by the price-fighting Trump Administration by criticizing the payer rebates that hack into net sales. Meanwhile, even after a public lashing from Trump on price hikes, Read said Pfizer's ready to return to "business as normal" in 2019, indicating that price increases are likely on the way. (Sagonowsky, 11/2)

    The Economist: The White House Makes A Last-Minute Proposal On Drug Prices Such exceptional disparities in drug prices are typical in America. Pharmaceutical spending is the highest in the OECD club of mostly rich countries, at $1,174 per person—more than twice as much as in Britain. Voters have grown tired of the price- gouging. Over the past five years, prices of the 20 most-prescribed brand-name drugs have rocketed at ten times the rate of inflation. Out-of-pocket costs, the cash payments made for treatment that are not covered by health-insurance premiums, have spiked. For these reasons, health care has been the subject of nearly half of all political advertisements on television in the run-up to the mid-terms. (11/3)

    Stat: Skin Cancer Immunotherapy Could Have Potential But Don't Hang Hopes On New Data OncoSec Medical (ONCS), a biotechnology company focused on combination immunotherapies, offered anecdotal evidence last year suggesting its novel approach might help some skin cancer patients who do not benefit from the currently approved class of drugs known as checkpoint inhibitors. What OncoSec lacked was data from a clinical trial to hang its hopes on. On Tuesday, the company tried to remedy that scientific shortcoming, but the newly released sliver of data on the drug, called Tavo, are frustratingly early and hard to interpret. (Feuerstein, 11/6)

    Bloomberg: Big Employers Will Use Online Startup To Save On Medicine Costs  A group of large employers plans to use a new online prescription-savings tool as they confront high drug costs and try to steer patients to the most cost-effective medicines. The Health Transformation Alliance, a coalition of more than 40 big companies that includes IBM Corp., Verizon Communications Inc. and American Express Co., has agreed to use a new online tool from startup Rx Savings Solutions to help the millions of people who work for the group’s members get better deals on their medications. (Langreth, 11/1)

    Stat: Can Novartis Charge $4 Million For A One-Time Drug?  Novartis believes its new gene therapy is worth more than $4 million for a one-time dose, and the company has some data to back that up. But, with a global spotlight on the escalating cost of medicine, is it politically viable to set a new record for the world’s most expensive drug? The treatment, called AVXS-101, has demonstrated dramatic effects in spinal muscular atrophy, a rare genetic disorder whose most severe form is fatal for almost all patients before age 2. In a 15-patient trial, infants with SMA who got AVXS-101 had a 100 percent survival rate after 24 months, data that convinced Novartis to pay $8.7 billion for the gene therapy’s inventor. (Garde, 11/5)

    FiercePharma: Gilead Investors Spooked By UnitedHealthcare Push To Cut HIV Drug Costs The ongoing war over drug prices has spawned numerous cost-saving initiatives from payers and the federal government, and now a new program from UnitedHealthcare has Gilead Sciences feeling the hurt. Unveiled this week, UnitedHealthcare’s MyScriptRewards program will offer patients up to $500 in prepaid debit cards for medical expenses if they work with their doctors to choose lower-cost HIV drug regimens. The program is rolling out in HIV antivirals to start, with other specialty drug classes to follow. (Sagonowsky, 11/1)

    The Wall Street Journal: Eli Lilly Raises 2018 Guidance After Strong 3Q Eli Lilly & Co. on Tuesday raised its adjusted earnings per share guidance as it reported a more than doubled third-quarter profit. The Indianapolis, Ind.-based drugmaker earned a quarterly profit of $1.15 billion, or $1.12 a share, compared with $555.6 million, or 53 cents, for the same period last year. Excluding items, Eli Lilly reported an adjusted profit of $1.39 a share for the quarter, compared with $1.05 last year and analysts forecasts of $1.15. (Walker, 11/6)

    Reuters: Sanofi And Regeneron's Dupixent Gets More Positive Feedback From U.S. FDA The U.S. Food & Drug Administration (FDA) regulator has given more positive feedback on the Dupixent eczema treatment being developed by drugmakers Sanofi and Regeneron, the companies said on Tuesday. Dupixent was launched in the United States in April 2017 for the treatment of moderate-to-severe eczema in adults, and the product is seen as a key sales driver for both companies. (11/6)

    This is part of the KHN Morning Briefing, a summary of health policy coverage from major news organizations. Sign up for an email subscription.


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